Ligand Binding Domain, to functional equivalents of this protein such as the TdT binding protein (Entrez Protein Accession Number BAB62888.1) and to the use of this protein, its functional equivalents and nucleic acid sequence from the encoding genes in the diagnosis, prevention and treatment of ...
专利名称：LIGAND BINDING DOMAINS OF NUCLEAR HORMONE RECEPTORS 发明人：PHELPS, Christopher, Benjamin,FAGAN,Richard, Joseph,ALLEN, Janet,Marjorie,ALLEN, Kathryn,Elizabeth,STANCOVSKI, Ilana,PIERRON,Valerie, Nathalie,PHILLIPS, Tom,HUNT,Caroline, Ann 申请号：EP03738304.9 申请日：20030702 公开号：EP151995...
摘要: This invention relates to a novel protein, termed LBDG3, herein identified as a Nuclear Hormone Receptor Ligand Binding Domain and to the use of this protein and nucleic acid sequence from the encoding genes in the diagnosis, prevention and treatment of disease....
The farnesoid X receptor (FXR, NR1H4) has been recognized as an attractive therapeutic target because it is a nuclear hormone receptor that controls the expression level of cholesterol-7α-hydroxylase, which in turn regulates bile acid production and cholesterol excretion. To compare receptor activit...
Nuclear hormone receptors are a class of transcription factors whose activity depends on the binding of a ligand. The proteins are structurally and functionally related and include the receptors for steroid hormones, thyroid hormone and ... MG Parker - 《Seminars in Cancer Biology》 被引量: 96发...
Also, ligand binding domains (LBD) of several nuclear hormone receptors (Braselmann et al., 1993; Wang et al., 1994; Burcin et al., 1999), and activation domains (AD) derived from herpes simplex virus (Baim et al., 1991; Gossen and Bujard, 1992; Braselmann et al., 1993; Wang et...
Structure of the retinoid X receptor alpha DNA binding domain: A helix required for homodimeric... Describes the three-dimensional solution structure of the DNA binding domain (DBD) of the retinoid X receptor alpha (RXRalpha). Use of nuclear magnetic re... Lee,Min,S.,... - 《Science》 ...
In addition, co-activators and chromatin remodellers may also be recruited through ligand-dependent TR occupancy of chromatin, a mechanism shared with other steroid hormone receptors such as GR, PR and AR. 12 T3 de novo (n=961) T3 remodelled (n=1,548) 10 Unchanged (n=72,897) 8 6 4...
Cellular response to changes in the concentration of different chemical species in the extracellular medium is induced by ligand binding to dedicated transmembrane receptors. Receptor density, distribution, and clustering may be key spatial features that influence effective and proper physical and biochemical...
These data show that hsp90 selectively recognizes the altered ER ligand-binding domain containing the G400V substitution and indicate that the wild-type ER ligand-binding domain of VP16-GAL-ERdoes not interact with hsp90 . Hormone binding studies showed that the ligand-binding domain of VP16-...