Megalizzi V, Le Mercier M, Decaestecker C: Sigma receptors and their ligands in cancer biology: overview and new perspectives for cancer therapy. Med Res Rev 2012, 32: 410–427. 10.1002/med.20218Megalizzi, V.: Le Mercier, M.: Decaestecker, C. Sigma receptors and their ligands in ...
S. SalomonCell Biology and Preclinical Models UnitBentham Science PublishersCurrent Drug TargetsNormanno N, Bianco C, Strizzi L, Mancino M, Maiello MR, De Luca A et al. (2005). The ErbB receptors and their ligands in cancer: an overview. Curr Drug Targets 6: 243-257....
EPH receptors (EPHs), together with cell-bound signalling-competent ligands (ephrins), regulate cell positioning, tissue patterning and stem cell maintenance during normal and neoplastic development. Their specialized functions are driven via the signalling of oligomeric EPH–ephrin clusters into both int...
In recent years a number of natural products were disclosed as ligands of NRs and proved to have remarkable affinity and in some cases peculiar mode of action. In this review the natural ligands of the subfamily NR1, NR2, and NR3 will be described with an emphasis to their mechanisms of ...
关键词: Animals Humans Mice Rats Cardiovascular System Nervous System Ovarian Neoplasms Receptors, G-Protein-Coupled Receptors, Lysophospholipid Ligands DOI: 10.1146/annurev.biochem.73.011303.073731 被引量: 1747 年份: 2004 收藏 引用 批量引用 报错 分享 全部来源 免费下载 求助全文 dx.doi.org Oxford ...
nature publishing group Review ErbB receptors and their growth factor ligands in pediatric intestinal inflammation Mark R. Frey1,2,3 and D. Brent Polk1,2,3 The ErbB tyrosine kinases (epidermal growth factor receptor (EGFR), ErbB2/HER2, ErbB3, and ErbB4) are cell surface growth factor ...
(integral) proteins that bind to external ligand molecules. This type of receptor spans the plasma membrane and performs signal transduction, in which an extracellular signal is converted into an intercellular signal. Ligands that interact with cell-surface receptors do not have to enter the cell ...
Bergelson JM, Chan BM, Finberg RW, Hemler ME: The integrin VLA-2 binds echovirus 1 and extracellular matrix ligands by different mechanisms. J Clin Invest 92: 232–239, 1993 ArticleCASGoogle Scholar Santoso S, Kalb R, Walka M, Kiefel V, Müller-Eckhardt C, Newman PJ: The human platele...
These classes include the growth factor receptors, the transporter receptors which internalize their ligands, ion channels, and G-protein-coupled receptors. In the past few years, the cDNAs and/or genes of a number of G-protein-coupled receptors have been cloned. Structural analysis of the G-...
Here, I review the structure, ligands, signalling modes and functions of TREMs in humans and mice and discuss the challenges that remain in understanding TREM biology. This is a preview of subscription content, access via your institution Access options Access Nature and 54 other Nature ...