Megalizzi V, Le Mercier M, Decaestecker C: Sigma receptors and their ligands in cancer biology: overview and new perspectives for cancer therapy. Med Res Rev 2012, 32: 410–427. 10.1002/med.20218Megalizzi, V.: Le Mercier, M.: Decaestecker, C. Sigma receptors and their ligands in ...
membrane-anchored (integral) proteins that bind to external ligand molecules. This type of receptor spans the plasma membrane and performs signal transduction, in which an extracellular signal is converted into an intercellular signal. Ligands that interact with cell-surface receptors do not have to e...
Here, authors introduce GzESTY, a sensitive cell-based assay that can detect receptor activation and revealed the presence of endogenous ligands in raw tissue extracts. Luca Franchini Joseph J. Porter Cesare Orlandi ResearchOpen Access15 May 2025 Nature Communications Volume: 16, P: 4521 ...
Here, I review the structure, ligands, signalling modes and functions of TREMs in humans and mice and discuss the challenges that remain in understanding TREM biology. This is a preview of subscription content, access via your institution Access options Access through your institution Access ...
The tumor necrosis factor (TNF) family of related receptors and ligands contains a rich collection of molecules that are important players in a broad spectrum of biological systems. While several family members are critical for development and function of the immune system, providing both activation ...
and vitamin D receptors have been developed. Peroxisome proliferator-activated receptors (PPARs) comprise another important NR subfamily, consisting of three different isotypes: PPARα, PPARδ (PPARβ) and PPARγ. These NRs are activated by a variety of natural and synthetic ligands such as fatty...
Deorphanization, i.e., unambiguous pairing of cognate ligands and receptors, has consistently transformed the understanding of human biology (Civelli et al., 2013), and illumination of understudied drug targets is a key objective of modern drug discovery (Oprea et al., 2018, Roth and Kroeze, ...
ligands used for in vitro assays are labeled with either [125I] or [3H]. While [125I]-labeled ligands show a higher specific activity (∼ 2000 Ci/mmol) and shorter half-life (t1/2 = 60 days) compared to tritium-labeled ligands (specific activity ~ 25–120 Ci/mmol andt1/...
between hormone receptors in family B have shown that the amino-terminal extracellular domain is essential for ligand binding but that the transmem- brane domains and associated extracellular loop regions of the receptors provide critical information necessary for spe- cific interaction with ligands. Al...
In vivo ligands of MDA5 and RIG-I in measles virus-infected cells. PLoS Pathog. 10, e1004081 (2014). PubMed PubMed Central Google Scholar Sanchez David, R. Y. et al. Comparative analysis of viral RNA signatures on different RIG-I-like receptors. eLife 5, e11275 (2016). PubMed ...