The hormone-binding domain of Oreochromis aureus estrogen receptor gene: homology comparison with other steroid binding receptors. DNA Seq. 5, 371-379.N.S. Tan, T.J. Lam, J.L. Ding, The hormone-binding do- main of Oreochromis aureus estrogen receptor gene Homol- ogy comparison with other ...
To determine the importance of specific amino acids in the hormone-binding domain of the human glucocorticoid receptor (hGR), we have generated mutants M565R, G567A, and A573Q. In hormone binding assays using [3H]cortisol, half-maximal saturation of dexamethasone competition was achieved at 10...
Regulation of heterologous proteins by fusion to a hormone binding domainRegulation of heterologous proteins by fusion to a hormone binding domainPicard, DidierPicard, D. Regulation of heterologous proteins by fusion to a hormone binding domain. In: D. Picard (ed.), Nuclear Receptors: A Practical...
The human c-erbAβ protooncogene encodes a thyroid hormone receptor (comprising a hormone-binding domain and a DNA-binding domain) which modulates expression of specific genes, such as cell differentiation genes. Using the reverse transcription and polymerase chain reaction (RT-PCR) assay, significant...
To understand the function of cysteines, we have substituted cysteines 638, 643, and 665 by serine in the hormone-binding domain (HBD) of the human glucocorticoid receptor (hGR). In hormone-binding assays using [3H]dexamethasone, hGR C643S and hGR C665S exhibited wild type receptor Kd of...
Steroid-binding domain Abbreviations SHBG sex hormone-binding globulin, also known as testosterone-estradiol-binding globulin (TeBG) and sex-steroid-binding protein (SBP) ABP androgen-binding protein Δ6-testosterone 17β-hydroxyandrosta-4,6-dien-3-one SSPE 150 mM NaCl/10 mM NaH2PO4H2O/1 mM EDT...
The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Reprints and permissions About this article Cite this article Luo, J., Chen, Q., Shen, T. et al. Association ...
7Citations 3Altmetric Abstract Sex steroids are implicated in the etiology of the metabolic syndrome (MetS) with different effects in men and women that likely reflect the sex dimorphic balance between circulating testosterone and estradiol levels. In men, low testosterone levels are a major risk fa...
The crystal structure of human sex hormone-binding globulin (SHBG) has revealed how 5alpha-dihydrotestosterone intercalates between the two seven-stranded beta-sheets of its amino-terminal laminin G-like domain. However, a region of disorder (residues 130 to 135 of SHBG) was identified together...
GL15256 had no functional prediction in NCBI and InterPro, but it showed a domain signature named kazal domain. The fourth most abundant, GI22948, was predicted as a mesencephalic astrocyte-derived neurotrophic factor homolog, and the fifth GI24315 as a heat shock protein 90 family protein. ...