Receptor databases and computational websites for ligand binding. Methods Mol. Biol. 897, 1-13.B.K. Rana, P.A. Insel, Receptor databases and computational websites for ligand binding, Methods Mol. Biol. 306 (2005) 1-15.Rana BK, Bourne PE, Insel PA (2012) Receptor databases and ...
This chapter discusses ligand binding to receptors from the point of view of molecular mechanism and pharmacological consequences. The ratio of rates determines the amount of drug bound to the receptor at any one instant and this becomes a measure of how well the drug binds to the receptor. Li...
The advent of recombinant production of receptors has contributed to the increased availability of specific assays and some aspects of the expression of recombinant receptors will be reviewed. Applications of receptor–ligand binding assays described in this review will relate to screening and the ...
Allatostatins (AST) are neuropeptides with variable function ranging from regulation of developmental processes to the feeding behavior in insects. They exert their effects by binding to cognate GPCRs, called Allatostatin receptors (AlstR), which emerge
网络接受器与质体配对关系 网络释义 1. 接受器与质体配对关系 另一款经由细胞接受器与质体配对关系(receptor-ligand),如去氧核醣核甘酸疫苗、胜肽疫苗抗体、细胞激素(cytokines)、压力 … www1.cgmh.org.tw|基于 1 个网页
Intracellular signaling upon Pep/Gal-PNPs binding The cellular effects of insulin are initiated at the cell membrane by binding to the insulin receptor (IR), which can stimulate the intracellular PI3K/AKT pathway and elicit the phosphorylation of AKT (p-AKT)30. Thus, as an increase in intracel...
Regulation of endothelial cell and platelet receptor-ligand binding by the 12- and 15-lipoxygenase monohydroxides, 12-, 15-HETE and 13-HODE. In previous studies, we reported that vascular wall cells such as endothelial cells metabolize linoleic acid to 13-hydroxyoctadecadienoic acid (13-HODE) vi...
Neuropeptide Y Yreceptors in the rat forebrain: Autoradiographic demonstration of [I][Leu,Pro]-NPY binding sites and neurons expressing Yreceptor mRNA Using the specific monoiodinated analog [Leu31,Pro34]-we have localized sites of the type in forebrain areas of the . The resulting receptor aut...
Binding to membrane and nuclear receptors As a second showcase, we present the binding of two small organic molecules to a pharmacologically relevant membrane protein, namely the adenosine A2Areceptor (A2AR). It belongs to the class A of the GPCRs. The GPCR superfamily is a major therapeutic ...
Binding of ligands to their homologous receptors, which activate specific cell signaling pathways, is a basic type of cellular communication and intimately linked to many degeneration processes leading to diseases. Main body This study reviewed the history of ligand-receptor and presents the databases ...