Ah receptor, a novel ligand-activated transcription factor - Sogawa, Fujii-Kuriyama - 1997 () Citation Context ...ducing activities were via activating Keap1-Nrf2 pathway [5], while bifunctional inducers’ attributed to the activation of the aryl hydrocarbon (Ah) receptor-xenobiotic response ...
Transcription factor EB (TFEB) is a master regulator of autophagy by inducing the expression of genes involved in autophagic and lysosomal degradation. In breast cancer, ligand-activated progesterone receptor has been reported to influence cancer development by manipulating the autophagy pathway. However,...
INTRODUCTION: Agonists of the ligand-activated transcription factors PPARγ and PPARα are in routine clinical use for Type 2 diabetes and lipid control. In vitro studies suggest that PPARγ and PPARα exert antiproliferative and anti-invasive effects on gliomas. PPAR may therefore have a role as...
L-6 The Ah-receptor cDNA is a Novel Ligand Activated Transcription Factor. Kristine Μ. Burbach', Alan Poland' and Christopher A. Bradfield'. 'Department of Pharmacology, Northwestern University Medical School, Chicago, IL, USA. 'McArdle Laboratory for Cancer Research, Madison, Wl USA. Cloning...
After more than fifty years of intensive research, the aryl hydrocarbon receptor (AHR) has been established as a ligand-activated transcription factor that plays a critical role in various physiological processes, including xenobiotic metabolism, cell proliferation and development1,2. Recently, it has ...
The ligand activated transcription factor, aryl hydrocarbon receptor (AhR) emerged as a critical regulator of immune and metabolic processes in the gastrointestinal tract. In the gut, a main source of AhR ligands derives from commensal bacteria. However,
The glucocorticoid receptor (GR) is a ligand-activated transcription factor. In this study, we used the yeast two-hybrid system to isolate cDNAs encoding proteins that interact with the human GR ligand-binding domain (LBD) in a ligand-dependent manner. One isolated cDNA from a HeLa cell librar...
Aryl hydrocarbon receptor (AhR), a member of the bHLH–PAS family, is a ligand-activated transcription factor which plays an important role in normal liver development and in mediating the toxicity of polycyclic and halogenated aromatic hydrocarbon pollutants such as 2,3,7,8-tetrachlorodibenzo-p-di...
配体进化受体配体结合and核受体的核受体配体受体与核受体配体结合的 系统标签: receptorligandbindingnuclear受体evolution Ligandbindingandnuclear receptorevolution HectorEscriva,FranckDelaunay,andVincentLaudet* Summary Nuclearreceptorsformasuperfamilyofligand-activated transcriptionfactorsthatregulatevariousphysiological functions...
Peroxisome proliferator-activated receptor γ (PPARγ) is a major therapeutic target for the treatment of type 2 diabetes. However, the use of PPARγ-targeted drugs, such as rosiglitazone and pioglitazone, is limited owing to serious side effects caused by classical agonism. Using a rational drug...