网络配体激活的 网络释义 1. 配体激活的 这类被配体激活的(ligand-activated)GPCR蛋白中第一个成功拿到蛋白结晶体的就是β2肾上腺素能受体蛋白,这可是Kobilka … www.lifeomics.com|基于 1 个网页 例句
Ligand-activated peroxisome proliferator-activated receptor-δ and -γ inhibit lipopolysaccharide-primed release of high mobility group box 1 through upregulation of SIRT1. Cell Death Dis. 2014, 5, e1432. [CrossRef] [PubMed]Hwang JS, Lee WJ, Kang ES, Ham SA, Yoo T, Paek KS, Lim DS, ...
ligand effectslithiummetalationzincatesMetalation of N-phenylpyrrole by using an in situ mixture of ZnCl2TMEDA (0.5equiv; TMEDA=N,N,N,N-tetramethylethylenediamine) and LiTMP (1.5equiv; TMP=2,2,6,6-tetramethylpiperidino) was optimized. The reaction carried out at room temperature in THF ...
In breast cancer, ligand-activated progesterone receptor has been reported to influence cancer development by manipulating the autophagy pathway. However, understanding of the mechanism that underlies the autophagic response remains limited. Herein, we report that prolonged treatment with progestin R5020 up...
In this study we examined the effect of ligand-activated PPARgamma on placental development and transplacental fatty acid transport in wild-type (wt) and PPARgamma(+/-) embryos. We found that exposure of pregnant mice to the PPARgamma agonist rosiglitazone for 8 d (embryonic d 10.5-18.5) ...
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Nuclear hormone receptors: ligand-activated regulators of transcription and diverse cell responses.doi:10.1016/S1074-5521(96)90143-XSignal transduction via nuclear hormone receptors is unusual in that the hormone ligand forms an integral part of the protein complex involved in DNA binding and ...
aThe ligand-activated intracellular signalling pathways result in neutrophil migration to the site of inflammation. CXCR1 is a class A, rhodopsin-like G-protein-coupled receptor, the largest class of integral membrane proteins responsible for cellular signal transduction and targeted as drug receptors li...
Kundert, K., Lucas, J.E., Watters, K.E.et al.Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs.Nat Commun10, 2127 (2019). https://doi.org/10.1038/s41467-019-09985-2 Download citation Received16 May 2018 ...
INTRODUCTION: Agonists of the ligand-activated transcription factors PPARγ and PPARα are in routine clinical use for Type 2 diabetes and lipid control. In vitro studies suggest that PPARγ and PPARα exert antiproliferative and anti-invasive effects on gliomas. PPAR may therefore have a role as...