A group of transcription factors named ligand activated nuclear receptors (LANR) influence and regulate important liver functions, and can be activatedby many xenobiotic compounds, which thereby can cause hepatotoxicity. Systematic analysis of the gene pathways regulated by LANR using modern 鈥榦mics ...
In practice, the cascade of biochemical reactions initiated by activated receptor is a series of Michaelis–Menten-like reactions that can be modeled by a single mathematical function of the Michaelis–Menten form. The maximal response of most tissues to powerful natural agonists is produced by ...
The receptors demonstrated to transactivate TGFBR include multiple receptors of the G-protein coupled receptor (GPCR) families and toll-like receptor 4 (TLR4) [111, 114, 115]. The GPCR agonist, thrombin, signals via its cognate protease-activated receptor-1 (PAR-1) to transactivate TGFBR in ...
The peroxisome proliferator-activated receptors (PPAR)伪,尾/未, and纬are ligand-activated nuclear receptors involved in a number of physiological processes, including lipid and glucose homeostasis, inflammation, cell growth, differentiat... P Receptors,D Genini,CV Catapano 被引量: 52发表: 2008年 ...
G protein-coupled receptors (GPCRs) are the largest class of transmembrane proteins, making them an important target for therapeutics. Activation of these receptors is modulated by orthosteric ligands, which stabilize one or several states within a compl
Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Bone remodelling and bone loss are controlled by a balance between the tumour necrosis factor family molecule osteoprotegerin ligand (OPGL) and its decoy r... YY Kong,U Feige,I Sarosi,....
Because the integrin beta 1 cytoplasmic domain appears to have a focal contact localization signal, there must be a mechanism by which this domain is kept inactive in the unoccupied state and becomes exposed or activated in the occupied receptor. We considered that this mechanism involves the ...
receptors that are now activated by antiestrogen and inhibited by estrogen. The ER point mutant L540Q is activated by several antiestrogens (the more pure antiestrogens ICI 164,384 and RU 54,876 or the partial antiestrogen trans-hydroxytamoxifen) but not by estradiol. The presence of the F ...
Transcription coactivators for peroxisome proliferator-activated receptors. Peroxisome proliferator-activated receptors (PPARs) regulate diverse biological processes such as development, differentiation, neoplastic conversion, infl... S Yu,JK Reddy - BBA - Molecular and Cell Biology of Lipids 被引量: 667发...
The purpose of this investigation was to determine what structural changes convert "inert" alphaIIbbeta3 integrins into "activated" high-affinity receptors for adhesive proteins. Light scattering, analytical ultracentrifugation, electron microscopy, and molecular modeling were used to probe the conformational...