These transcription factors are located in the nucleus (21). Thus, transport of the fatty acids from the cytoplasm to the nucleus would seem to be required for interaction with nuclear transcription factors. L-FABP is an obvious candidate for this transport function. Tissue-specific FABPs have ...
Hormonal regulation of gene activity is mediated by nuclear receptors acting as ligand-activated transcription factors. Intermediary factors interacting wi... Thenot,S. - 《Journal of Biological Chemistry》 被引量: 152发表: 1997年 Response Element and Coactivator-Mediated Conformational Change of the ...
The growth inhibition of dividing cells and most of the transcriptional responses upon TGF-beta treatment depend on the Smad2, Smad3, and Smad4 transcription factors. These proteins shuttle continuously between the cytoplasm and the nucleus, transmitting the ligand status of the TGF-beta receptors ...
In addition, ligand-activated ER can interact with other factors to alter the physiology and growth of cells. Using a yeast two-hybrid screen, we have identified an interaction between ER alpha and the proapoptotic forkhead transcription factor FKHR. The ER alpha-FKHR interaction depends on beta...
TFE3 and TFEB are broadly expressed transcription factors related to the transcription factor Mitf. Although they have been linked to cytokine signaling pathways in nonlymphoid cells, their function in T cells is unknown. TFE3-deficient mice are phenotyp
Transforming growth factor-beta (TGF-beta) elicits a variety of cellular activities primarily through a signaling cascade mediated by two key transcription factors, Smad2 and Smad3. Numerous regulatory mechanisms exist to control the activity of Smad3, thereby modulating the strength and specificity of...
展开 关键词: Animals Humans Cell Line Tumor Cells, Cultured Cell Nucleus Prostatic Neoplasms Transcription Factors Cytoskeletal Proteins DNA-Binding Proteins Trans-Activators DOI: 10.1038/sj.onc.1206049 被引量: 262 年份: 2002 收藏 引用 批量引用 报错 分享 全部...
On the other hand, HDL-mediated signal transducer and activator of transcription 3 activation in macrophages involves S1PR2 and S1PR3 (35). HDL signaling in endothelial cells also involves SR-B1, both S1PR1 and S1PR3 and HDL-associated S1P (37). Conditional inactivation of S1pr1 gene ...
The glucocorticoid receptor (GR) is a ligand-dependent transcription factor which regulates growth, development and metabolic functions. To test the hypoth... CL Yu,N Yap,D Chen,... - 《Cancer Letters》 被引量: 51发表: 1997年 The Androgens and Androgen Receptors in Development, Differentiation...
The creation of genetic switches can also benefit from the combination of modular components; eukaryotic transcription factors, for example, are amenable to engineering largely because their DNA binding and transcriptional activation domains are independent [6]. The ability of RNA to form functional modu...