and Asn-179. In conclusion, contact with Met-292 and Phe-86, which are unique positions of α1A, accounts for mirabegron binding to α1A. Because of its lack of interactions with the binding pocket, mirabegron has lower affinity compared to α1A-blockers and no effects on voiding symptom...
There is a high risk that ligands will be falsely linked to some cell-intrinsic genes because the cell-type-specific genes are assumed to be induced by cell–cell interactions with other cell types [15]. In addition to imputing inter- and intracellular communication by integrating paired L–R...
the integration of additional centers of charge into the peptide molecule would strongly increment the number of different patterns of intramolecular electrostatic interactions. As a considerable consequence, the ensemble-averaged values of structural parameters might lose statistical significance due to high ...