The glial cell line derived neurotrophic factor (GDNF) family has recently been expanded to include four members, and the interactions between these neurotrophic factors and their unique receptor system is now beginning to be understood. Furthermore, analysis of mice lacking the genes for GDNF, ...
The ligand for GFRα3, artemin, was recently shown to bind to the GFRα3 receptor and to be a survival factor for different sensory and sympathetic neurons (23). The latest member of this growing family is GFRα4 (24). It was reported that persephin binds to GFRα4 and that co-...
欧洲知识产权局专利: EP2580242B1 . 2016-04-06 机译: Sorla与GDNF家庭配体受体之间相互作用的调节 5. Modulation of the Interaction Between SorLA and GDNF-Family Ligand Receptors [P] . 美国专利: US2015239973A1 . 2015-08-27 机译: SorLA和GDNF家庭配体受体之间相互作用的调节。 获取...
Activation of the receptor tyrosine kinase RET, which can be achieved either by interactions between GDNF receptor-α subunits and GDNF family members or by various oncogenic mutations, results in distinct cellular outcomes, including proliferation, differentiation, surviv- npg Role of the interaction ...
Activation of the receptor tyrosine kinase RET, which can be achieved either by interactions between GDNF receptor-α subunits and GDNF family members or by various oncogenic mutations, results in distinct cellular outcomes, including proliferation, differentiation, surviv- npg Role of the interaction ...
Kawashima N, Yoon SJ, Itoh K, Nakayama K (2009) Tyrosine kinase activity of epidermal growth factor receptor is regulated by GM3 binding through carbohydrate to carbohydrate interactions. J Biol Chem 284(10):6147–6155. https://doi.org/10.1074/jbc.M808171200 Article CAS PubMed Google Scholar...
平台分析来自癌症基因组图谱(The Cancer Genome Atlas,TCGA)数据集的脑GBM与正常脑组织的m RNA表达数据,结果显示NRP1,NRP2和整合素β-1(Integrin beta-1,ITGB1)表达显著增加,而胶质细胞系源性神经营养因子受体α1(GDNF family receptor alpha 1,GFRA1),受体酪氨酸激酶(receptor tyrosine kinase,RET),神经细胞粘附...
The GDNF family ligands signal through a receptor complex composed of a ligand binding subunit, GFRalpha, and a signaling subunit, the RET tyrosine kinase... H Enomoto,I Hughes,J Golden,... - 《Neuron》 被引量: 0发表: 2004年 加载更多来源...
Here we show that the Rho-family guanine nucleotide exchange factor protein Vav2 is required for DAT cell surface expression and transporter activity modulated by glial cell line–derived neurotrophic factor (GDNF) and its cognate receptor Ret. Mice deficient in either Vav2 or Ret displayed ...
Adoptive T cell immunotherapy using chimeric antigen receptor (CAR)-modified T cells (CAR Ts) is showing encouraging results in the treatment of cancer, but development is challenged by the availability of suitable target antigens. We identified glial-derived neurotrophic factor (GDNF) family ...