and Asn-179. In conclusion, contact with Met-292 and Phe-86, which are unique positions of α1A, accounts for mirabegron binding to α1A. Because of its lack of interactions with the binding pocket, mirabegron has lower affinity compared to α1A-blockers and no effects on voiding symptom...
There is a high risk that ligands will be falsely linked to some cell-intrinsic genes because the cell-type-specific genes are assumed to be induced by cell–cell interactions with other cell types [15]. In addition to imputing inter- and intracellular communication by integrating paired L–R...