然而,人脐带间充质干细胞来源的外泌体(hucMSCs-exo)可以恢复CVB3引起的改变。Let-7a-5p富集于hucMSCs-exo中,且hucMSCs-exolet-7a-5pmimic对CVB3诱导的铁死亡的抑制作用高于hucMSCs-exomimic NC。在VMC组中,SMAD2表达升高,而ZFP...
Let-7a-5p is a microRNA, which inhibits migration, invasion, as well as epithelial-mesenchymal transition by targeting several oncogenes. Moreover, cell proliferation, colony formation, migration and invasion were decreased after induced overexpression of let-7a in breast cancer cells. Deregulation ...
本发明将人脐带间充质干细胞外泌体中的let7a5p应用在制备治疗病毒性心肌炎的药物中;所述外泌体中let7a5p通过介导SMAD2以促进ZFP36表达的途径抑制CVB3诱导的心肌细胞铁死亡,实现对病毒性心肌炎的治疗.本发明通过研究证明了人脐带间充质干细胞外泌体中let7a5p如何缓解CVB3诱导病毒性心肌炎这一过程,根据CVB3诱导病毒...
目的探讨let-7a-5p靶向调节转化生长因子一β受体1(transforming growth factor-β receptor 1,TGF-βR1)在急性呼吸窘迫综合征中作用及机制.方法 NIH3T3细胞经转染let-7a-5p pmimics或let-7a-5p inhibitor等后,分为1et-7a-5p增强组,let-7a-5p增强对照组,let...
bbe-let-7a-5p qPCR试剂盒 分类:microRNA qPCR Kits 品牌:BioTNT 货号:bbe-let-7a-5p 原价:￥4030 现价:￥3098.38 节省:￥932 规格:1 kits 说明:bbe-let-7a-5p 特异性茎环引物试剂盒 ￥615产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式...
gga-let-7a-5p qPCR试剂盒 分类:microRNA qPCR Kits 品牌:BioTNT 货号:gga-let-7a-5p 原价:￥4030 现价:￥3098.38 节省:￥932 规格:1 kits 说明:gga-let-7a-5p 特异性茎环引物试剂盒 ￥615产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式...
货号:bfl-let-7a-5p 原价:￥4030 现价:￥3098.38节省:￥932 规格:1 kits 说明:bfl-let-7a-5p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录产物...
抗结核外泌体miRNA的筛选与mmu-let-7a-5p调控巨噬细胞凋亡影响胞内BCG细菌负荷的作用研究 目的寻找并筛选具有抗结核功能的外泌体mi RNA并通过体外细胞功能实验明确mmu-let-7a-5p对Raw264.7单核巨噬细胞凋亡的调控作用及其对胞内感染的BCG细菌负荷的影响.方法... 詹学华 - 宁夏医科大学 被引量: 0发表: 2022年...
Pneumoconiosis, Lung cancer, Dust exposure, Exosome, Let-7a-5pBackgroundEither chronic or acute exposure to dust particles may lead to pneumoconiosis and lung cancer, and lung cancer mortality among patients diagnosed with pneumoconiosis is increasing. Utilizing genome-wide sequencing technology, this ...
At multivariate analysis, only let-7a-5p was significantly associated with EFS (p = 0.009) and OS (p = 0.0008). Conclusion: Up-regulation of the above miRNAs could represent biomarkers in breast cancer. 展开 关键词: subtypes breast cancer miRNAs breast cancer treatment chemotherapy integrated ...