然而,人脐带间充质干细胞来源的外泌体(hucMSCs-exo)可以恢复CVB3引起的改变。Let-7a-5p富集于hucMSCs-exo中,且hucMSCs-exolet-7a-5pmimic对CVB3诱导的铁死亡的抑制作用高于hucMSCs-exomimic NC。在VMC组中,SMAD2表达升高,而ZFP...
The let-7 miRNA family consists of 11 closely related genes. The gene for let-7a is located on the chromosome 22q13.31 and is associated with CpG islands. Let-7a-5p is a microRNA, which inhibits migration, invasion, as well as epithelial-mesenchymal transition by targeting several oncogenes...
Srebf2 mechanistically interacts with the metabolic effect of let-7a-5p and participates in lipid accumulation by regulating Srebf2 downstream signaling. Moreover, let-7a-5p binds to Thbs1 to interact with the PI3K-AKT-mTOR pathway, down-regulating the phosphorylation levels of AKT,...
通过进一步对let-7b靶基因筛查,发现其中15个靶基因与p53信号通路(CASP3、CCND1、CCND2、FAS等)和细胞周期(CCND1、CCND2、CDC25A等)相关,认为let-7b可能通过影响P53信号通路和细胞周期的调控在内异症发病中促进子宫内膜细胞向肌层浸润[2]。近期有研究在造模内异症小鼠血清中发现let-7a-5p 的表达显著降低,let-7b...
bbe-let-7a-5p qPCR试剂盒 分类:microRNA qPCR Kits 品牌:BioTNT 货号:bbe-let-7a-5p 原价:￥4030 现价:￥3098.38 节省:￥932 规格:1 kits 说明:bbe-let-7a-5p 特异性茎环引物试剂盒 ￥615产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式...
gga-let-7a-5p qPCR试剂盒 分类:microRNA qPCR Kits 品牌:BioTNT 货号:gga-let-7a-5p 原价:￥4030 现价:￥3098.38 节省:￥932 规格:1 kits 说明:gga-let-7a-5p 特异性茎环引物试剂盒 ￥615产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式...
目的探讨let-7a-5p靶向调节转化生长因子一β受体1(transforming growth factor-β receptor 1,TGF-βR1)在急性呼吸窘迫综合征中作用及机制.方法 NIH3T3细胞经转染let-7a-5p pmimics或let-7a-5p inhibitor等后,分为1et-7a-5p增强组,let-7a-5p增强对照组,let...
货号:bfl-let-7a-5p 原价:￥4030 现价:￥3098.38节省:￥932 规格:1 kits 说明:bfl-let-7a-5p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录产物...
货号:tch-let-7a-5p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:tch-let-7a-5p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录...
Pneumoconiosis, Lung cancer, Dust exposure, Exosome, Let-7a-5pBackgroundEither chronic or acute exposure to dust particles may lead to pneumoconiosis and lung cancer, and lung cancer mortality among patients diagnosed with pneumoconiosis is increasing. Utilizing genome-wide sequencing technology, this ...