Expression of this mimic led to a significant decrease in endogenous ABCC2 mRNA and protein levels in a Huhliver cell line, which could be blocked by expression of a let7a mimic inhibitor. Injection of a lentivirus let7a inhibitor into normal mouse liver or into mouse liver after common bile...
其中5个miRNA(let-7a-3p、let-7d-3p、miR-30d-5p、miR-183-5p和miR-182-5p)在血浆外泌体中表现出一致的变化趋势,3个(let-7a-3p、let-7d-3p和miR-30d-5p)在癌组织和癌旁组织中的表达存在显著差异。然而,8个miRNA中的另...
抗结核外泌体miRNA的筛选与mmu-let-7a-5p调控巨噬细胞凋亡影响胞内BCG细菌负荷的作用研究 目的寻找并筛选具有抗结核功能的外泌体mi RNA并通过体外细胞功能实验明确mmu-let-7a-5p对Raw264.7单核巨噬细胞凋亡的调控作用及其对胞内感染的BCG细菌负荷的影响.方法... 詹学华 - 宁夏医科大学 被引量: 0发表: 2022年...
Uterine miR-877-3p and let-7a-5p are increased during simulated menstruation in a mouse model 来自 科研支点 喜欢 0 阅读量: 16 作者:M Watters,CA Walker,AA Murray,M Nicol,JA Maybin 摘要: Lay summary Heavy periods are common and debilitating, but we do not fully understand how they are ...
Hsa-Let-7a:乳腺癌 Hsa-Let-7b:恶性间皮瘤,淋巴瘤 Hsa-Let-7c:肝癌 Hsa-Let-7d:卵巢癌 Hsa-Let-7e:恶性间皮瘤 Hsa-Let-7f:糖尿病 Hsa-Let-7g:肝癌 Hsa-Let-7i:淋巴瘤 Hsa-Mir-21:胃癌 Hsa-Mir-34家族 Hsa-Mir-34a:乳腺癌 Hsa-Mir-34b: 非小细胞肺癌 Hsa-Mir-34c-5p:非小细胞肺癌 Hsa-Mi...
用Target Scan数据库预测到miR-129-5p直接与COL1A1 mRNA的3'UTR结合,是COL1A1转录后调节因子(图5)。 2.7 miR-129-5p在胃癌中的表达水平与生存预后分析 经OncomiR数据库检索发现,miR-129-5p在胃癌组织中的表达显著低于正常组织(P=3.32e-05,图7A)。为分析miR-129-5p与胃癌生存预后之间的关系,我们使用此数据...
and lung cancer through sponging miRNA16,17,18. We chose the miRanda database to predict miRNA that could possibly bind to LINC00319. The results indicated that miR-199a-5p and let-7a-5p may potentially bind to LINC00319 with high conservation. However, only miR-199a-5p showed a negative...
结果:1.Let-7b-5p和miR-320a-3p在头颈鳞癌组织和细胞系中的表达水平对TCGA数据库数据分析结果显示CCR7在头颈鳞癌原发灶中表达水平高于正常组织,并且在肿瘤不同分期,不同阶段表达量均高于正常组织.Real-time PCR检测结果表明let-7b-5p和miR-320a-3p在头颈鳞癌组织中表达量低于癌旁组织.Let-7b-5p在PCI-37A细胞...
高,miR-122-5p表达降低，生物信息学软件预测靶基因多集中于细胞凋亡及免疫应答过程。结论NS1感 染后可能通过上调let-7c-5p表达及下调miR-122-5p表达来调控细胞凋亡及抑制免疫应答。【关键词】呼吸道合胞病毒;非结构蛋白:miRNAs doi：10.3969/j.issn.1004-5511.2019.02.011 【中图分类号JR373.1【文献标识码】...
To validate the sequencing results, we investigated the relative expression levels by randomly selecting 6 mRNAs (Bsn, Ecel1, En2, Mag, PKD2L1, Syt17) and 6 miRNAs (mmu-let-7a-5p, mmu-let-7d-5p, mmu-miR-106b-5p, mmu-miR-130a-5p, mmu-miR-135a-5p, mmu-miR-221-5p) by q-PCR ...