LEF1-AS1long non-coding RNAacute myeloid malignancyLEF1 antisense RNA 1 (LEF1‐AS1) is an antisense long non‐coding RNA encoded in the lymphoid enhancer‐binding factor 1 (LEF1) locus. LEF1‐AS1 is a conserved transcript dysregulated in hematopoiesis. This study aimed to functionally ...
通过干扰皮肤鳞状细胞癌SCC13细胞LEF1-AS1的表达和过表达、抑制miR-612的表达,将SCC13细胞分为转染LEF1-AS1干扰序列、无义序列的干扰LEF1-AS1组、干扰对照组,转染miR-612过表达序列、无义序列的miR-612过表达组、过表达对照组,以及...
Easily measurable in the blood, the long noncoding RNA LEF1-AS1 has recently been associated with in-hospital mortality following SARS-CoV 2 infection and holds potential as a biomarker for disease severity in COVID-19 patients. Consequently, we examined LEF1-AS1's ability to predict ...
LEF1-AS1FZD2CD44Wnt/β-catenin背景:长链非编码RNA(Long Non-coding RNAs,lnc RNAs)是多种癌症在生物学过程中非常重要的功能调节因子之一.近年来,很多科学家对其进行了研究,但是lnc RNA调控雄激素非依赖性前列腺癌(CRPC)发展的机制仍然不是很清楚.方法:采用高通量测序技术和q RT-PCR技术,检测了CRPC组织及邻近...
The 5-year overall survival in GBM patients from The Cancer Genome Atlas with high expression of LEF1-AS1 was inferior to that with low expression. It was confirmed that expression of LEF1-AS1 was higher in GBM tissues than normal ones. Knockdown of LEF1-AS1 significantly inhibited...
1反义RNA 1(LEF1-AS1)是一种长链非编码RNA(long noncoding RNA,lnc RNA),有证据表明LEF1-AS1在多种癌症中异常表达,且与癌症的发生发展密切相关.然而,LEF1-AS1在泛癌中的作用尚不清楚.本研究旨在探讨LEF1-AS1在泛癌中的表达,预后价值及免疫相关性,并进一步分析LEF1-AS1在胃癌中的表达和临床意义.方法:1....
PCR和双荧光素酶报告基因试验分析LEF1-AS1与miR-212-5p的靶向关系.结果显示,IL-1β处理显著增加软骨细胞的凋亡率(P<0.05),增加IL-6,TNF-α和IFN-γ的分泌量(P<0.05),上调LEF1-AS1表达(P=0.000),下调miR-212-5p表达(P=0.000).抑制LEF1-AS1表达或过表达miR-212-5p可降低IL-1β诱导的软骨细胞的凋亡率...
Altered FUT8 also regulates the core fucosylation of CRC cells, and LEF1-AS1 mediates FUT8 level through activation of Wnt/尾-catenin/LEF1 pathway, thereby resulting in 尾-catenin nuclear translocation. In addition, LEF1-AS1 mediates the proliferat...
We found that the lncRNA LEF1-AS1 was expressed at low levels in the RASFs and inhibited their abnormal proliferation by targeting PIK3R2 protein and regulating the PI3K/AKT signal pathway through its interaction with miR-30-5p. In this study, we fabricated a nano-drug delivery system for ...
LEF1-AS1 acted as a competitive endogenous RNA and promoted the expression of S100A11 by competitively binding to miR-489-3p and enhancing the proliferation, migration, and angiogenesis of HUVEC cells. Thus, LEF1-AS1 participated in the occurrence and development of venous malfor...