Large granular lymphocyte (LGL) leukemia is a rare lymphoproliferative malignancy that arises from either CD3+ mature cytotoxic T-cell or CD3- natural killer (NK)-cell lineage. It is a heterogeneous disorder due to distinct morphological, immunophenotypical, and clinical features among patients, ...
LGL cells play an integral role in the immune system and are divided ... RJ Watters,X Liu,TP Loughran - 《Leukemia & Lymphoma》 被引量: 43发表: 2011年 T-cell and natural killer-cell large granular lymphocyte leukemia neoplasias Large granular lymphocyte (LGL) leukemia is a rare disorder ...
Large granular lymphocyte (LGL) leukemia is a rare disorder of mature cytotoxic T or natural killer cells. Large granular lymphocyte leukemia is characterized by the accumulation of cytotoxic cells in blood and infiltration in the bone marrow, liver, and spleen. Herein, we review clinical features...
Large granular lymphocyte leukemia. Oncologist. 2006;11:263–73. Article CAS PubMed Google Scholar Komrokji RS, Ali NA, Sallman D, Padron E, Lancet J, Sokol L, et al. Characterization of myelodysplastic syndromes (MDS) with T-cell large granular lymphocyte proliferations (LGL). Leukemia....
T-Large Granular Lymphocyte Leukemia Accompanied by an Increase of Natural Killer Cells (CD3-)...Reports on the case of a 65-year-old male patient with T-large granular lymphocytes (LGL) leukemia complicated with natural killer cell-large granular lymphocyte (NK-LGL). Clinical presentation; ...
Leukemia, LymphoidWe describe the first case of an Epstein-Barr virus (EBV)-associated natural killer-large granular lymphocyte (NK-LGL) leukemia in the United States to the best of our knowledge. A 29-year-old woman of Japanese descent developed EBV infection after a blood transfusion as ...
Seroreactivity to LGL leukemia-specific epitopes in aplastic anemia, myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria: Results of a bone ma... Large granular lymphocyte (LGL) leukemia is characterized by clonal expansion of antigen-activated cytotoxic T cells (CTL). Patients frequently exh...
The central hypothesis of our laboratory research program in large granular lymphocyte (LGL) leukemia is that leukemic LGL represent antigen-driven cytotoxic T lymphocytes (CTL) with characteristics of dysregulated apoptosis. The clinical features of LGL leukemia highlight the association of autoimmune dis...
et al. Spontaneous remission of large granular lymphocyte T cell leukemia. Leukemia 13, 313–314 (1999). https://doi.org/10.1038/sj.leu.2401304 Download citation Received01 September 1998 Accepted03 November 1998 Published05 February 1999 Issue Date01 February 1999 DOIhttps://doi.org/10.1038/sj...
We report a patient with large granular lymphocyte (LGL) leukemia whose proliferating LGLs expressed CD3 but not WT31-reactive Ti antigen, and they exhibited strong non-major histocompatibility complex (MHC)-restricted cytotoxicity. MATERIALS AND METHODS Case report. A 60-year-old female was ...