DiagnosisLarge granular lymphocytic leukemiaSTAT3TreatmentPURPOSE OF REVIEW :This manuscript aims at updating the knowledge on the clinico-biological characteristics, pathogenesis, and the diagnostic challenges of T-LGLL and CLPD-NK disorders and reviews the advances in the management and treatment of ...
Questions diagnosis of acute large granular lymphocytic leukemia. A letter to the editor along with response from author is presented in response to the article "Allogeneic hematopoietic cell transplantation in a dog with acute large granular lymphocytic leukemia" by S.E. Suter, M.J., Hamilton and...
T-cell clones of uncertain significance are highly prevalent and show close resemblance to T-cell large granular lymphocytic leukemia. Implications for laboratory diagnostics Abstract Benign clonal T-cell expansions in reactive immune responses often complicate the laboratory diagnosis T-cell neoplasia. We ...
Using CD8+ T-LGL leukemia as a model disease, we have set out to evaluate and compare the Vβ TCR deep-sequencing spectra of both patients and healthy controls to better understand how TCR deep sequencing could be used in the diagnosis and monitoring of not only T-LGL leukemia but also ...
Pure Red Cell Aplasia Due to T-Cell Large Granular Lymphocytic Leukemia After Hematopoietic Stem Cell Transplantation In contrast, here we present a case of postHSCT donor-derived T-LGLL that led to pure red cell aplasia with severe patient morbidity. After diagnosis,... A Rangan,JL Oliveira,...
Objective To summarize the diagnosis and treatment of Sj?gren’s syndrome complicated with T large granular lymphocytic leukemia. Method A case was investigated retrospectively. Result The patient was a 66-year-old woman with a history of dry mouth and dry eyes for many years.The symptoms were ...
Past studies described occasional patients with myeloid neoplasms (MN) and coexistent large granular lymphocytic leukemia (LGLL) or T-cell clonopathy of unknown significance (TCUS), which may represent expansion of myeloid clonal hematopoiesis (CH) as triggers or targets of clonal cytotoxic T cell...
A case of γδ T-cell large granular lymphocytic leukemia due to a chronic active Epstein-Barr virus infection in systemic lupus erythematosus☆Author links open overlay panelMomoko Okamoto a 1, Kunihiro Ichinose a 1, Shinya Sato b, Ken-Ichi Imadome c...
Large granular lymphocytic leukemia (LGLL) is an indolent disease and often associated with autoimmune disorders such as rheumatoid arthritis. The association of humoral immune disorders resulting from abnormal B cell activity, may affect original LGLL pathogenesis, clinical presentation and management throug...
Systematicsequencing in patients with unexplained cytopenias identifies unsuspected large granular lymphocytic leukemia.Elizabeth A MorganMark N LeeDaniel J DeAngelo