Large Granular Lymphocytic Leukemia (LGLL), a rare lymphoproliferative disorder of T cell or Natural Killer cell (NK) origin is characterized by persistent immunodominant clones of CD3+ Cytotoxic T Lymphocyte (CTLs) or CD3- NK cells. Dysregulated homeostasis of CTL and NK cells may be due to ...
Past studies described occasional patients with myeloid neoplasms (MN) and coexistent large granular lymphocytic leukemia (LGLL) or T-cell clonopathy of unknown significance (TCUS), which may represent expansion of myeloid clonal hematopoiesis (CH) as triggers or targets of clonal cytotoxic T cell...
Questions diagnosis of acute large granular lymphocytic leukemia. A letter to the editor along with response from author is presented in response to the article "Allogeneic hematopoietic cell transplantation in a dog with... Fish,Eric,J.,... - 《Journal of the American Veterinary Medical Associati...
Large Granular Lymphocytic Leukemia (LGLL) is a rare lymphoproliferative clonal disorder of mature cytotoxic effector memory T-cells or natural killer cells involving blood, bone marrow and spleen. In the majority of cases, it has an indolent clinical behavior and can be associated, at the time ...
Hemolytic anemia in chronic large granular lymphocytic leukemia of natural killer cells: cytotoxicity of natural killer cells against autolougous red cells is associated with hemolysis. Transfusion 1996 ; 36: 463–466Gilsanz F,De La Serna J,Moltó L,Alvarez-Mon M.Hemolytic anemia in chronic large...
The article presents a case study of a 64-year-old male with CD4 /NKa /CD8dim T-cell large granular lymphocytic leukemia who presented with complaints of persistent lymphocytosis for the past 17 years. Flowcytometric immunophenotypic analysis was performed on an ethylenediamin...
T cell large granular lymphocytic (T-LGL) leukemia is a rare type of mature T cell neoplasm. The typical features of T-LGL leukemia include an increased number of large granular lymphocytes in the peripheral blood, cytopenia (most commonly neutropenia), and mild-to-moderate splenomegaly. Up to...
These cases require more aggressive therapy with acute lymphoblastic leukemia regimens. We report a case of fatal CD56 negative T cell large granular lymphocytic leukemia in a 38year old lady. 展开 关键词: Large granular lymphocytes Aggressive variant CD56 negative ...
Large granular lymphocytic leukemia (LGLL) is an indolent disease and often associated with autoimmune disorders such as rheumatoid arthritis. The association of humoral immune disorders resulting from abnormal B cell activity, may affec... H Awada,J Durrani,A Kishtagari,... - 《Blood》 被引量:...
Large granular lymphocytic leukemia (LGLL) is an indolent disease and often associated with autoimmune disorders such as rheumatoid arthritis. The association of humoral immune disorders resulting from abnormal B cell activity, may affect original LGLL pathogenesis, clinical presentation and management throug...