1998. Unequal fidelity of leading strand and lagging strand DNA replication on the Escherichia coli chromosome. Proc. Natl. Acad. Sci. USA 95:10020-10025.Fijalkowska IJ, Jonczyk P, Tkaczyk MM, Bialoskorska M, Schaaper RM (1998) Unequal fidelity of leading strand and lagging strand DNA ...
Explain why DNA polymerase can continuously add fragments onto the leading strands 3'-5', but cannot do the same for the lagging strand. During transcription, on which strand will RNA polymerase be located? What is the role of DNA ligase in the elongation? What is the...
coli is not the result of DNA repair processes. Furthermore, we show that the Okazaki fragments contain about equal amounts of leading- and lagging-strand sequences. These results are most consistent with the discontinuous DNA replication model as originally proposed by Okazaki et al. 展开 ...
In DNA synthesis, 2 additional DNA strands are formed. One of the strands, known as leading strand, is continuously created throughout DNA replication. The other, known as the lagging strand, is produced in pieces. This results in two semi-conservative...
2007 . The eukaryotic leading and lagging strand DNA polymerases are loaded onto primer-ends via separate mechanisms but have comparable processivity in the ... O.,Chilkova,P.,... - 《Nucleic Acids Research》 被引量: 130发表: 2007年 The eukaryotic leading and lagging strand DNA polymerases ...
后随链(lagging strand): 答案 在一个复制叉中不连续合成的链叫后随链。 结果二 题目 名词解释后随链(lagging strand) 答案 后随链:在DNA复制过程中,另一股链因为复制方向与解链方向相反,不能连续延长,只能随着模板链的解开,逐段地从 5'→3^('') 生成引物并复制子链,这一不连续复制的链称为后随链。
Remarkably, DNA synthesis progresses further along the lagging strand than the leading strand, resulting in the exposure of long stretches of single-stranded leading-strand template. The asymmetric DNA synthesis in rad53-1 cells is suppressed by elevated levels of dNTPs in vivo, and the activity ...
aFurthermore, in the absence of WRN, leading- and lagging-strand DNA synthesis are uncoupled at replication forks, and POT1 is required for efficient replication of C-rich telomere strands 此外,在没有WRN时,铅和绝热材料子线脱氧核糖核酸综合被拆在复制叉子,并且POT1为富有C的telomere子线的高效率的...
滞后链(lagging strand) 点击查看答案 第4题 The function of DNA polymerase I is to replace RNA primer with DNA. On which strand would you expect DNA polymerase I to be more active? A、the leading strand B、the lagging strand C、equally active on both strands D、neither , only DNA poly...
PCNA performs distinct functions during leading and lagging strand DNA replication: On the leading strand, PCNA supports continuous DNA synthesis by recruiting and facilitating the function of Polε. On the lagging strand, PCNA recruits Polδ to synthesize Okazaki fragments (OFs) by extending RNA ...