What is leading strand in DNA replication? Is DNA polymerase 1 used in the leading strand? If RNA polymerase is responsible for separating DNA strands during transcription, then what does Helicase do? Explain why DNA polymerase can continuously add fragments onto the leading s...
Thus, the overhangs at the leading and lagging daughter telomeres are generated differently in human cells, and telomerase may preferentially affect overhangs generated at the telomeres produced by leading-strand synthesis. 展开 关键词: DNA DOI: 10.1016/j.molcel.2005.12.004 被引量: 247 ...
Chai W, Du Q, Shay JW, Wright WE (2006a) Human telomeres have different overhang sizes at leading versus lagging strands. Mol Cell 21:427–435 View ArticleChai W,Du Q,Shay JW. Human telomeres have different overhang sizes at leading versus lagging strands[J].Molecules and Cells 2006,21....
Describe the function of primase in leading strand synthesis in DNA synthesis. Describe the function of helicase in leading strand synthesis in DNA synthesis. Describe the structure of DNA and the steps of protein synthesis. What role do the existing strands of DNA play durin...
We show that the divergence rate of orthologs situated on leading strands is lower than the divergence rate of those situated on lagging strands. The ratio of the mutation accumulation rate for sequences lying on lagging strands to that of sequences lying on leading strands is rather stable and...
We also examined the distribution of these sequences on leading and lagging strands. We obtained another four statistically significant LDR sequences with more than 187 bp matched to LDR-A near the LDR loci, suggesting that these regions might be used as high recombination hot spots for LDR. ...
We show here that the perfect palindrome can form hairpin DNA structures on the templates of the leading- and lagging-strands in a replication-dependent reaction. In the presence of the hairpin endonuclease SbcCD, both copies of the replicated chromosome containing the perfect palindrome are cleaved...
aFurthermore, in the absence of WRN, leading- and lagging-strand DNA synthesis are uncoupled at replication forks, and POT1 is required for efficient replication of C-rich telomere strands 此外,在没有WRN时,铅和绝热材料子线脱氧核糖核酸综合被拆在复制叉子,并且POT1为富有C的telomere子线的高效率的...
Eukaryotic Translesion DNA Synthesis on the Leading and Lagging Strands: Unique Detours around the Same Obstacle 来自 ACS 喜欢 0 阅读量: 35 作者:M Hedglin,SJ Benkovic 摘要: During S-phase, minor DNA damage may be overcome by DNA damage tolerance (DDT) pathways that bypass such obstacles, ...
the BrdU alkaline comet assay can detect ssDNA gaps in situations where only one of the complementary nascent DNA strands bears gaps, as opposed to the previously described S1 nuclease-based approach, where the readout necessitates the simultaneous presence of leading and lagging strand gaps. HeLa...