What is the basis for the difference in how the leading and lagging strands of DNA molecules are synthesized? a. The origins of replication occur only at the 5′ end. b. Helicases and single-strand binding proteins work at the 5′ end. c. DNA polymerase can join new nucleotides only to...
Fuchs.Uncoupling of Leading- and Lagging-Strand DNA Replication During Lesion Bypass in Vivo. Science . 2003V. Pages, R.P. Fuchs, Uncoupling of leading- and lagging-strand DNA replica- tion during lesion bypass in vivo, Science 300 (2003) 1300-1303....
前导链是指随着亲本双螺旋的解开而按照5′ 3′方向连续合成的DNA子链,以3′5′方向的亲本链为模板。 Lagging stand uses the DNA strand that runs 5’ to 3’as template and synthesis DNA non-continuously as Okazaki fragment. It's synthesis requires multiple priming events. A series of ...
aFurthermore, in the absence of WRN, leading- and lagging-strand DNA synthesis are uncoupled at replication forks, and POT1 is required for efficient replication of C-rich telomere strands 此外,在没有WRN时,铅和绝热材料子线脱氧核糖核酸综合被拆在复制叉子,并且POT1为富有C的telomere子线的高效率的...
In DNA synthesis, 2 additional DNA strands are formed. One of the strands, known as leading strand, is continuously created throughout DNA replication. The other, known as the lagging strand, is produced in pieces. This results in two semi-conservative...
2007 . The eukaryotic leading and lagging strand DNA polymerases are loaded onto primer-ends via separate mechanisms but have comparable processivity in the ... O.,Chilkova,P.,... - 《Nucleic Acids Research》 被引量: 130发表: 2007年 The eukaryotic leading and lagging strand DNA polymerases ...
Identify each of the enzymes involved in DNA replication and whether they are used during the synthesis of the leading strand, lagging strand, or both. Describe the function of DNA ligase in lagging strand synthesis in DNA synthesis. Describe leading strand and lagging st...
Currently, it is unclear how this critical pathway unfolds, in particular, where and when TLS occurs on each template strand. Given the semidiscontinuous nature of DNA replication, it is likely that TLS on the leading and lagging strand templates is unique for each strand. Since the discovery ...
In rad53-1 cells stressed by dNTP depletion, the replicative DNA helicase, MCM, and the leading-strand DNA polymerase, Pol ε, move beyond the site of DNA synthesis, likely unwinding template DNA. Remarkably, DNA synthesis progresses further along the lagging strand than the leading strand, ...
DNA replication is significantly different on leading and lagging strands- Replication in the leading strand is typically continuous, whereas the...Become a member and unlock all Study Answers Start today. Try it now Create an account Ask a question Our experts can answer your tough h...