Fuchs.Uncoupling of Leading- and Lagging-Strand DNA Replication During Lesion Bypass in Vivo. Science . 2003V. Pages, R.P. Fuchs, Uncoupling of leading- and lagging-strand DNA replica- tion during lesion bypass in vivo, Science 300 (2003) 1300-1303....
Which DNA polymerase synthesizes the leading strand? What is the role of RNA polymerase in protein synthesis? What role does DNA helicase play in replication? What is the role of DNA helicase during DNA replication? What is the lagging strand in DNA replication? What is...
In DNA synthesis, 2 additional DNA strands are formed. One of the strands, known as leading strand, is continuously created throughout DNA replication. The other, known as the lagging strand, is produced in pieces. This results in two semi-conservative...
It is primed one time during synthesis and uses the DNA strand 3’ to 5’ as template. 前导链是指随着亲本双螺旋的解开而按照5′ 3′方向连续合成的DNA子链,以3′5′方向的亲本链为模板。 Lagging stand uses the DNA strand that runs 5’ to 3’as template and synthesis DNA non-...
aFurthermore, in the absence of WRN, leading- and lagging-strand DNA synthesis are uncoupled at replication forks, and POT1 is required for efficient replication of C-rich telomere strands 此外,在没有WRN时,铅和绝热材料子线脱氧核糖核酸综合被拆在复制叉子,并且POT1为富有C的telomere子线的高效率的...
We have asked whether exonucleolytic proofreading occurs during simian virus 40 origin-dependent, bidirectional DNA replication in extracts of human HeLa cells. In addition, we have compared the fidelity of leading and lagging strand DNA synthesis. In a fidelity assay that scores single-base substit...
百度试题 结果1 题目半不连续性: 领头链(leading strand) 随从链(lagging strand) 冈崎片段(Okazaki fragment)相关知识点: 试题来源: 解析 pol I,pol III 反馈 收藏
Gene 4 protein and DNA polymerase catalyze processive leading strand synthesis. Gene 4 protein molecules serving as helicase remain bound to the template as leading strand synthesis proceeds greater than 40 kilobases. Primer synthesis for lagging strand synthesis is catalyzed by additional gene 4 ...
This finding supports the dimeric DNA polymerase model [(1980) J. Biol. Chem. 255, 4290–4303], which proposes that DNA polymerases δ and α act coordinately as leading and lagging strand enzymes, respectively, at the replication fork. 展开 ...
Therefore, we propose that DNA replication checkpoint kinases function to couple leading- and lagging-strand DNA synthesis under replication stress, thereby preventing the generation of long stretches of ssDNA. Results To understand how Rad53 functions to maintain replisome integrity, we first analyzed ...