The overexpression of wild-type KRAS significantly stimulated cell migration, which is further promoted by KRAS (G12V) [54, 55]. Combined, the observations of these resistance mechanisms help to develop new combination therapeutics overcoming clinical drug resistance [53]. In conclusion, the possible...
Wild-typeKRAS(KRASWT) amplification has been shown to be a secondary means of KRAS activation in cancer and associated with poor survival. Nevertheless, the precise role ofKRASWToverexpression in lung cancer progression is largely unexplored. Here, we identify and characterize a KRAS-responsive lncR...
Growth inhibitory effect of wild-type Kras2 gene on a colonic adenocarcinoma cell line. World J Gastroenterol. 2007; 13 :934–938.Li H, Cao HF, Wan J, Li Y, Zhu ML, Zhao P (2007) Growth inhibitory effect of wild-type Kras2 gene on a colonic adenocarcinoma cell line. World J ...
We demonstrate that FASN, the rate-limiting enzyme in FA synthesis, while being dispensable in EGFR-mutant or wild-type KRAS LC, is required for the viability of KMLC cells. Integrating lipidomic, transcriptomic and functional analyses, we demonstrate that FASN provides saturated and monounsaturated...
2、Targeting wild-typeKRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition(通过组合的MEK和SHP2抑制靶向野生型KRAS扩增的胃食管癌); 3、SHP2 is required for growth ofKRAS-mutant non-small-cell lung cancer in vivo(SHP2是KRAS突变型非小细胞肺癌体内生长所必需的)。
Wu等 [75] 和 Park 等 [76] 研究发现,KRAS 能够通过激活 ERK1/2、c-Jun 氨基末端激酶(c-Jun N-terminalkinase,JNK)及 PI3K 等信号蛋白介导的信号通路来诱导尿激酶型纤溶酶原激活物(urokinasetype plasminogen,uPA) 及其受体(urokinase-typeplasmino...
KRAS is one of front-line sensors that initiate the activation of an array of signaling molecules, allowing the transmission of transducing signals from the cell surface to the nucleus, and affecting a range of essential cellular processes such as cell differentiation, growth, chemotaxis and apoptosi...
(p.G13D) in these cell lines, without affecting the wild-type KRAS. Indels causing in-frame frameshifts were found to be the cause of this downregulation in mutant KRAS cells. They further investigated whether this would have an effect on cancer cell survival, proliferation, and tumorigenicity...
15. Ryan MB, et al. KRASG12C-independent feedback activation of wild-type RAS constrains KRASG12C inhibitor efficacy. Cell Rep. 2022 Jun 21;39(12):110993. 16. Hillig RC, et al. Discovery of potent SOS1 i...
The G-Quadruplex(GQ)-enriched promoter sequences were PCR (Polymerase chain reaction) amplified from the genomic DNA, isolated from MCF-7 cell line using wild-type (wt) primers ®(Promoter+GQ), which contain KpnI and HindIII restriction sites (Table S6). The PCR products were ...