此前,带有Wild-type KRAS而不依赖KRAS突变的自发胰腺癌小鼠模型极为匮乏。 本研究中,研究人员首先构建转基因小鼠模型,发现小鼠携带SMAD4缺失或者TGFBR2缺失,再联合p53缺失时,能够在Wild-type KRAS背景下诱导形成自发胰腺癌。 接下来,研究人员...
4. Philip PA, Azar I, Xiu J, et al. Molecular characterization of KRAS wild-type tumors in patients with pancreatic adenocarcinoma. Clin Cancer Res. 2022;28(12):2704-2714. 5. Fusco MJ, Saeed-Vafa D, Carballido EM, et al. Identif...
首页 / 癌基因 / KRAS / WILD TYPEKRAS(KRAS proto-oncogene, GTPase) KRAS (Kirsten Rat Sarcoma Viral Oncogene Homolog)基因是GDP/GTP结合蛋白,比较重要的同家族基因还包括HRAS和NRAS。KRAS与GTP结合呈激活状态,与GDP结合呈关闭状态,KRAS可被生长因子或酪氨酸激酶(如EGFR)短暂活化,活化后的KRAS可以激活下游如...
图三 全体患者（左）和PFS≤3个月的患者中KEAP1、SMARCA4 和 CDKN2A共突变的比例，图示Wild-type指野生型，Mut指突变型，only指单一共突变STK11也是早期进展患者中常见的共突变，不过详细分析发现，只有当KEAP1和STK11同时突变才与PFS和OS缩短显著相关。TP53也是常见共突变，不过其与疗效无关。图四 KEAP1野生型...
点击Create Group From Selected Diagram Areas,将这组数据命名为KRAS Wildtype。 点击Submit,之后在圆圈上册的一栏中选择KRAS Wildtype和KRAS Mutant,如下。 能看到两组的病人sample没有overlap。 因为我们这次要分析KRAS突变和没突变的两组基因表达差异,所以我们进入mRNA的页面。 在mRNA expression一栏中,μ代表mean ...
Wild-type KRAS (KRASWT) amplification has been shown to be a secondary means of KRAS activation in cancer and associated with poor survival. Nevertheless, the precise role of KRASWT overexpression in lung cancer progression is largely unexplored. Here, w
BENNOUNA J,HIRET S,BERTAUT A,et al. Continuation of bevacizumab vs cetuximab plus chemotherapy after first progression in KRAS wild-type metastatic colorectal cancer: the UNICANCER PRODIGE18 randomized clinical trial [J]. JAMA Oncol,2019,5(1):83-90. ...
11. Spira Alexander I, Tu Huakang, Aggarwal Shivani, et al. A retrospective observational study of the natural history of advanced non-small-cell lung cancer in patients with KRAS p.G12C mutated or wild-type disease.[J] .Lung Cancer, 2021, 159: 1-9. ...
Wild-type KRAS mediates growth inhibition and resistance to MEK inhibitors through dimerization with mutant KRAS in lung adenocarcinomadoi:10.1093/annonc/mdx361Ambrogio, C.Kohler, J.Zhou, Z.Wang, H.Paranal, R.Capelletti, M.Caffarra, C.
We demonstrate that FASN, the rate-limiting enzyme in FA synthesis, while being dispensable in EGFR-mutant or wild-type KRAS LC, is required for the viability of KMLC cells. Integrating lipidomic, transcriptomic and functional analyses, we demonstrate that FASN provides saturated and monounsaturated...