6. Topham JT, Tsang ES, Karasinska JM, et al. Integrative analysis of KRAS wildtype metastatic pancreatic ductal adenocarcinoma reveals mutation and expression-based similarities to cholangiocarcinoma. Nat Commun. 2022;13(1):5941. 7. Jones ...
6. Topham JT, Tsang ES, Karasinska JM, et al. Integrative analysis of KRAS wildtype metastatic pancreatic ductal adenocarcinoma reveals mutation and expression-based similarities to cholangiocarcinoma. Nat Commun. 2022;13(1):5941. (来源:肿瘤瞭望-消化时讯) 声明 凡署名原创的文章版权属《肿瘤瞭望》...
KRAS MUTATION IN EGFR WILD TYPE INDONESIAN LUNG CANCER PATIENTCOMMON AND UNCOMMON EGFR MUTATIONS ANALYSIS IN CYTOLOGY AND PLASMA SAMPLES OF TREATMENT-NAIVE LUNG CANCER PATIENTS NAJMIATUL MASYKURA, MUHAMMAD YUNUS, REFNIWITA YUSRIL, JAMAL ZAINI, SITA LAKSMI ANDARINI, ACHMAD HUDOYO, ELISNA SYAHR...
Consecutive patients with unresectable mCRC with documented KRAS mutation status treated at a single center from 2002 to 2013 with SIRT Y90 were investigated. Treatment response was compared between KRAS wild-type (wt) and mutant (mut) using an anatomic tumor response criteria based on RECIST 1.0...
The panel believes that patients with any known KRAS mutation, including G13D, should not be treated with cetuximab or panitumumab. 专家组认为,不应使用西妥昔单抗或帕尼单抗治疗具有任何已知KRAS突变(包括G13D)的患者。 P...
Loss of the wild-type KRAS allele promotes pancreatic cancer progression through functional activation of YAP1 Han Yan Chih-Chieh Yu Gloria H. Su Article18 Oct 2021 Oncogene The deubiquitinase USP16 functions as an oncogenic factor in K-RAS-driven lung tumorigenesis Guiqin Xu Zhaojuan Yang...
KRAS mutation analysis In both trials, mutational analysis of KRAS codons 12, 13, and 61 was conducted using a pyrosequencing approach, and analyzed using PyroMark Q24 1.0.9 software8. However, FIRE-3 only included patients who were KRAS wild-type at codons 12 and 137. ...
In June 2017, the FDA approved a refined indication for Vectibix for use in patients with wild-typeRAS(defined as wild-type in bothKRASandNRASas determined by an FDA-approved test for this use) mCRC, specifically as fir...
S. Methods:1.Wild type KRAS gene was am plified by PCR and cloned intolentivir al expressing vector and verified by se quencing. 2.G12D,G12V,G12A,G12S,G13D, Q61H mutational KRAS genes wereconstru cted by site—directed mutagenesis PCR ...
1). The selective inhibition of SOS1 could allow blockade irrespective of KRAS mutation type. The Boerhringer Ingelheim SOS 1 inhibitor, BI 1701963, has shown preclinical activity against G12 and G13 KRAS gene mutations and is being further developed alone and in combination with trametinib, a ...