6. Topham JT, Tsang ES, Karasinska JM, et al. Integrative analysis of KRAS wildtype metastatic pancreatic ductal adenocarcinoma reveals mutation and expression-based similarities to cholangiocarcinoma. Nat Commun. 2022;13(1):5941. 7. Jones ...
此前,带有Wild-type KRAS而不依赖KRAS突变的自发胰腺癌小鼠模型极为匮乏。 本研究中,研究人员首先构建转基因小鼠模型,发现小鼠携带SMAD4缺失或者TGFBR2缺失,再联合p53缺失时,能够在Wild-type KRAS背景下诱导形成自发胰腺癌。 接下来,研究人员...
Coexistence of KRAS mutation with mutant but not wild-type EGFR predicts response to tyrosine-kinase inhibitors in human lung cancer. Br J Cancer, 2014, 111(11): 2203-2204.Choughule A, Sharma R, Trivedi V, Thavamani A, Noronha V, Joshi A, et al. Coexistence of KRAS mutation with ...
6. Topham JT, Tsang ES, Karasinska JM, et al. Integrative analysis of KRAS wildtype metastatic pancreatic ductal adenocarcinoma reveals mutation and expression-based similarities to cholangiocarcinoma. Nat Commun. 2022;13(1):5941. (来源:肿瘤瞭望-消化时讯) 声明 凡署名原创的文章版权属《肿瘤瞭望》...
However, they predict contrasting response rates to tyrosine-kinase inhibitors (TKIs) – while EGFR mutation predicts longer progression-free survival rate (Lynch et al, 2004; www.bjcancer.com 2203 http-equiv="content-type"
mutation. While G12C mutations are frequently found in non-small cell lung cancer, these are relatively rare in pancreatic cancer. On the other hand, pancreatic cancer harbors other KRAS mutations such as G12D and G12V. The inhibitors targeting G12D mutation (such as MRTX1133) have been ...
KRAS mutation analysis In both trials, mutational analysis of KRAS codons 12, 13, and 61 was conducted using a pyrosequencing approach, and analyzed using PyroMark Q24 1.0.9 software8. However, FIRE-3 only included patients who were KRAS wild-type at codons 12 and 137. ...
KRAS mutation in lung metastases from colorectal cancer: prognostic implicationsdoi:10.1002/cam4.592BRAFbrain metastasescancercolorectalKRASlung metastasesKRAS mutant colorectal cancer (CRC) patients develop lung and brain metastases more frequently than KRAS wild-type (WT) counterpart. We retrospectively ...
Mutation of KIT and PDGFRA genes is implicated in the tumorigen... R Wada,H Arai,S Kure,... - 《Pathology International》 被引量: 12发表: 2016年 Enrichment of Mutant Alleles by Chromatographic Removal of Wild Type Alleles: a New Principle for the Detection of Alleles with Unknown Point ...
2). As such, the wild-type KRAS gene could be amplified and detected in all 35 DNA samples. Also, genomic DNA from a colon carcinoma known to harbor a Gly12Cys mutation in KRAS could be amplified and the mutation detected by RT-PCR (Fig. 2). This result indicates that the lack of...