The aim of this study is to find out the prevalence of two known main point mutations of KRAS gene (p.G12V/c.35G>T and p.G13D/c.38G>A) in addition to bioinformatics survey of its in Iranian patients with prostatic adenocarcinoma. A total of 35 p...
Clinical research presented at the European Society for Medical Oncology Congress 2024 highlights the significant survival benefits of perioperative and neoadjuvant immunotherapy with nivolumab and nivolumab plus ipilimumab, while emphasizing the role of biomarkers, such as circulating tumor DNA and KRAS muta...
All mutations were mutually exclusive. KRASG12V mutation was also detected in one cherry hemangioma-like hemangioma without GNA mutations. In summary, our study demonstrated recurrent GNA14/GNAQ/GNA11 mutations were present in the majority of this very common hemangioma and established its neoplastic ...
Virtually all classical and nonclassical HD cases also acquire somatic mutations, primarily in the RTK/RAS and phosphoinositide 3-kinase-signaling pathway genesKRAS,NRAS,FLT3, SOS, andPTPN11, as well as in the chromatin-modifying genesCREBBP,NSD2,SUV420H1,SETD2, andEZH2(Table1) [16,51,52,5...
Although meningiomas represent the most common class of tumors of the central nervous system, the molecular events underlying their genesis and development are still not well defined. In the present study we have used the immuno-blotting technique to study the expression level of the tumor suppressor...
of induction death [148,149]. However, this was not confirmed in patients who received ATO or ATRA-ATO [146]. Other commonly observed mutated genes includedWT1(14%),NRAS(10%),KRAS(4%),ETV6(1%), andEZH2(1%).DNMT3A,NPM1,TET2,IDH1,IDH2, andASXL1mutations were absent or rarely ...
We show that more than 99% of the earliest-stage, lowest-grade, pancreatic intraepithelial neoplasm-1 lesions contain mutations in KRAS, p16/CDKN2A, GNAS, or BRAF. These findings could improve our understanding of the development and progre...
A next-generation sequencing strategy for evaluating the most common genetic abnormalities in multiple myeloma. J. Mol. Diagn. 2017, 19, 99-106. [CrossRef] [PubMed]Jimenez, C.; Jara-Acevedo, M.; Corchete, L.A.; Castillo, D.; Ordonez, G.R.; Sarasquete, M.E.; Puig, N.; ...
21Citations Metrics Abstract Multiple gene-expression-based subtypes have been proposed for the molecular subdivision of colon cancer in the last decade. We aimed to cross-validate these classifiers to explore their concordance and their power to predict survival. A gene-chip-based database comprising...
Tran E, Ahmadzadeh M, Lu YC et al (2015) Immunogenicity of somatic mutations in human gastrointestinal cancers. Science 350(6266):1387–1390 Article CAS Google Scholar Tran E, Robbins PF, Lu YC et al (2016) T-cell transfer therapy targeting mutant KRAS in cancer. N Engl J Med 375(23...