Danysh, Brian P., Erin Y. Rieger, Deepankar K. Sinha, Caitlin V. Evers, Gilbert J. Cote, Maria E. Cabanillas, and Marie-Claude Hofmann. 2016. “Long-Term Vemurafenib Treatment Drives Inhibitor Resistance through a Spontaneous KRAS G12D Mutation in a BRAF V600E Papillary Thyroid Carcinoma ...
Mice harboring a potent dominant negative mutant thyroid hormone receptor β, TRβPV (ThrbPV/PV), spontaneously develop well-differentiated follicular thyroid cancer similar to human cancer. We genetically targeted the KrasG12D mutation to thyroid epithelial cells of ThrbPV/PV mice to understand how...
Therapeutically, KRAS mutation testing has maximum utility in stratifying metastatic colorectal carcinoma and lung cancer patients for treatment with targeted therapy. Diagnostically, KRAS mutation testing is useful in the workup of pancreaticobiliary and thyroid cancers, particularly using cytological ...
Further in vivo and in vitro validation of Naldemedine and its efficacy in targeting the pathogenic KRAS mutation are warranted. Keywords: Dynamic simulation; HRAS; KRAS; Missense mutation; Molecular docking; NRAS; Thyroid cancer; Virtual screening.甲状腺癌基因解码对甲状腺癌患者的有什么实用价值?
DUSP4/MKP2 overexpression is associated with BRAF(V600E) mutation and aggressive behavior of papillary thyroid cancer. The study was performed to retrospectively analyze the correlation of dual specificity phosphatase 4 (DUSP4) expression with clinicopathological variables ... Ben,Ma,Rongliang,... -...
Forexample, the mutation of KRAS gene in colorectal cancer patients, can benefitfrom the Cetuximab and Panitumumab EGFR antibody drug; in addition to the nonKRAS gene mutations in patients with advanced non-small cell lung cancer withGefitinib and Erlotinib EGFR tyrosine kinase inhibitor (TKI) ...
Protein Kinase inhibitors for the treatment of thyroid cancer: molecular mechanisms of resistance Though most types of thyroid cancer are cured by surgery and adjuvant radio- iodine therapy and TSH suppression, patients with radio-iodine refractory thyr... Magesh,Muthu - 《International Journal of Tub...
Conclusion:The radiomics models of ERUS images have great predictive value forKRASgene mutations in rectal cancer. It can be used as a supplementary method for non-invasive evaluation ofKRASgene mutations in rectal cancer patie...
(Taconic ncrnu-f, 6 weeks, 10 mice per group) under Dana-Farber Cancer Institute IACUC protocol 10–055. Tumor volume was measured twice a week based on caliper measurements of tumor length and height as volume = (length × width2)/2. A second investigator performed the tumor ...
(double mutation of KRAS, namely, glycine mutated to aspartic acid at the site G12 in HA-KRASK128R). The results showed that overexpression of FBXL6 dramatically enhanced the polyubiquitination of KRAS and its mutant (KRASG12D), which was remarkably inhibited by the mutation K128R (Fig.1f...