Kirsten rat sarcoma viral oncogene homologue (KRAS) is the best-known oncogene with the highest mutation rate among all cancers and is associated with a series of highly fatal cancers, including pancreatic ductal adenocarcinoma (PDAC), nonsmall-cell lung cancer (NSCLC), and colorectal cancer (CRC...
4. Jänne PA, Riely GJ, Gadgeel SM, et al: Adagrasib in non–small-cell lung cancer harboring a KRASG12C mutation. N Engl J Med 387:120-131, 2022 5. Fakih M G, Salvatore L, Esaki T, et al. Sotorasib plus panitumumab in refractory colorectal cancer with mutated KRAS G12C[J...
(KRAS)has attracted substantial attention.The understanding of KRAS is constantly being updated by numerous studies on KRAS in the initiation and progression of cancer diseases.However,KRAS has been deemed a challenging therapeutic target,even"undruggable",after drugtargeting efforts over the past four ...
M.H. HOFMANN, D. GERLACH, S. MISALE, et al. Expanding the Reach of Precision Oncology by Drugging All KRAS Mutants [J]. Cancer Discov, 2022, 12(4): 924-937.D. KIM, L. HERDEIS, D. RUDOLPH, et al. Pan-KRAS inhibitor disables oncogenic signalling and tumour growth [J]. Nature, ...
D. KIM, L. HERDEIS, D. RUDOLPH, et al. Pan-KRAS inhibitor disables oncogenic signalling and tumour growth [J]. Nature, 2023, 619(7968): 160-166. Huang, L., Guo, Z., Wang, F. et al. KRAS mutation: from undruggable to druggable in cancer. Sig Transduct Target Ther 6, 386 (202...
Huang, L., Guo, Z., Wang, F. et al. KRAS mutation: from undruggable to druggable in cancer. Sig Transduct Target Ther 6, 386 (2021). Hao Wang, Lingling Chi, Fuqiang Yu, Honglin Dai, Chao Gao, Xiaojie Si, Zhengjie Wang, Limin Liu, Jiaxin Zheng, Lihong Shan, Hongmin Liu, Qiurong...
首页/癌基因/KRAS/ MUTATION KRAS (Kirsten Rat Sarcoma Viral Oncogene Homolog)基因是GDP/GTP结合蛋白,比较重要的同家族基因还包括HRAS和NRAS。KRAS与GTP结合呈激活状态,与GDP结合呈关闭状态,KRAS可被生长因子或酪氨酸激酶(如EGFR)短暂活化,活化后的KRAS可以激活下游如控制细胞生成的PI3K-AKT-mTOR信号通路,以及控制细...
Huang, L., Guo, Z., Wang, F. et al. KRAS mutation: from undruggable to druggable in cancer. Sig Transduct Target Ther 6, 386 (2021). Hao Wang, Lingling Chi, Fuqiang Yu, Honglin Dai, Chao Gao, Xiaojie Si, Zhengjie Wang, Limin Liu, Jiaxin Zheng, Lihong Shan, Hongmin Liu, Qiurong...
3. Bekaii-Saab TS, Spira AI, Yaeger R, et al. KRYSTAL-1: updated activity and safety of adagrasib (MRTX849) in patients (Pts) with unresectable or metastatic pancreatic cancer (PDAC) and other gastrointestinal (GI) tumors harboring ...
KRAS的胚系突变(germline mutation)会影响发育过程中的RAS/MAPK信号传导,引发许多具有类似临床特征的多系统综合征,包括努南综合征(NS)、心-面-皮综合征(CFCS),以及罕见的Costello综合征(CS)。临床中把这一系列发育综合征称为“RASopathies”(RAS信号通路相关综合征),其特点是面部畸形、心脏缺陷、身材矮小和骨骼缺陷...