et al. DeepSAGE reveals genetic variants associated with alternative polyadenylation and expression of coding and non-coding transcripts. PLoS Genet. 9, e1003594 (2013). Article CAS PubMed PubMed Central Google Scholar ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the ...
Glioblastoma (GBM) has one of the worst 5-year survival rates of all cancers. While genomic studies of the disease have been performed, alterations in the non-coding regulatory regions of GBM have largely remained unexplored. We apply whole-genome sequencing (WGS) to identify non-coding mutation...
(RNA-seq) technology, researchers have identified novel transcripts not capable of being measured using conventional analyses.5–7 Using recently developed genomic tools, such as microarray and RNA-seq analysis, thousands of lincRNAs have been identified in mammals, but the functions of these linc...
protospacers were initially located in non-mobile chromosomal regions, suggesting that CRISPR might be playing in-house roles (Mojica et al.2005). Indeed, as is the case of the immune system in mammals (Sattler2017), non-canonical functions have been proven for the prokaryotic adaptive system s...
of the duplicated region (non-functionalization or sub-functionalization), or gain of new functional features (neo-functionalization). If the duplicated region was a cis-regulatory module, it evolves new regulatory functions over time, resulting in the genesis of new enhancers [52,53]. In a ...
However, the functions of these specific ORFs have not yet been identified. The bacteriocin-related holin-like peptide BhlA from Bacillus showed antibacterial activity against several Gram-positive bacteria, including MRSA and Micrococcus luteus by destroying cell mem- branes [122]. BhlA consists of...
of the hierarchical data structure includes one or more nodes, each node associated with an indication of a hash function and a boundary value; c) means for interrogating the hierarchical data structure using hashes of the input arbitrary-length bit string, the indicated hash functions and the ...
(3) depends not only on determining the correct unknowns, but also on the accuracy of the CMFs themselves. There are several sets of CMFs that could be used to derive cone spectral sensitivities. For the central 2° of vision, the main candidates are the CIE 1931 functions (CIE, 1932)...
of the duplicated region (non-functionalization or sub-functionalization), or gain of new functional features (neo-functionalization). If the duplicated region was a cis-regulatory module, it evolves new regulatory functions over time, resulting in the genesis of new enhancers [52,53]. In a ...
(Hypergeometric test and Bonferroni correction). Three genes used to infer this KDDA, including ARK1, PARP1, and TNF, were also effectively captured in the resulting subnetwork. The top ten enriched functions of this subnetwork were showed in Fig.3e. As expected, insulin resistance, type II ...