In the light of these data, in the review we consider the functional role of numerous known sequences of noncoding parts of the genome including introns, DNA methylation regions, enhancers and locus control regions, insulators, S/MAR sequences, pseudogenes, and genes of noncoding RNAs, as ...
An increasing number of long noncoding RNAs (lncRNAs) have experimentally confirmed functions, yet little is known about their transcriptional dynamics and it is challenging to determine their regulatory effects. Here, we used allele-sensitive single-cell RNA sequencing to demonstrate that, compared to...
The non-coding RNA promotes recovery from ultraviolet-induced DNA damage, antagonizing the function of the protein product of the coding transcript. Article CAS PubMed PubMed Central Google Scholar Khurana, E. et al. Role of non-coding sequence variants in cancer. Nat. Rev. Genet. 17, 93...
Previously, ncRNAs were assumed to be incapable of encoding proteins. However, recent discoveries have challenged this view, with the identification of a significant number of small open reading frames (sORFs) in noncoding regions of the genome [1]. These sORFs are known to produce peptides thro...
Canonical functions of TERC, telomerase inhibitors TERC is a non-coding RNA that serves as a template for telomere replication by telomerase, enabling the addition of TTAGGG repeats to maintain chromosomal stability. Its canonical role is critical for preserving telomere integrity and ensuring genomic ...
Evolution and Functions of Long Noncoding RNAs LOGO EvolutionandFunctionsofLongNoncodingRNAs Reporter:EnhuiShenSupervisor:LongjiangFanDate:2014/7/02 PontingCPetal.,Cell,2009;SaltaEetal.,TheLancetNeurology,2012;MaHetal.,TheScientificWorldJournal,2012.Contents 1 23 Introduction Classification Origins 4 Func...
Long non-coding RNAs (lncRNAs) are pervasively transcribed in the genome. They have important regulatory functions in chromatin remodeling and gene expression. Dysregulated lncRNAs have been studied in cancers, but their role in esophageal squamous cell carcinoma (ESCC) remains largely unknown. We hav...
According to the Encyclopedia of DNA Elements (ENCODE) project, about 75% of the human genome can be transcribed, but only about 1.5% of the DNA sequence codes for proteins. Historically, the 98% non-coding DNA with no biological function of encoding proteins was considered ‘junk DNA’ (Dj...
eRNAs are non-coding RNA molecules produced by the transcription of DNA cis-acting elements, enhancer fragments. Recent studies revealed that the transcription of eRNAs may be a biological marker responding to enhancer activity that can participate in the regulation of coding gene transcription. In ...
In contrast to protein-coding genes, long-noncoding RNAs (lncRNAs) are much less well understood, despite increasing evidence indicating a wide range of their biological functions, and possible roles in various cancers. Based on public RNA-seq datasets of four solid cancer types, we here utilize...