Non-coding DNA Function... Surprising?Michael White
和长非编码 RNA (lncRNA),它们是较长的 RNA,在调节基因活性方面具有多种作用。 染色体的一些结构元件也是非编码 DNA 的一部分。例如,染色体末端的重复非编码 DNA 序列形成 端粒。端粒保护染色体的末端在遗传物质的复制过程中不被降解。重复的非编码 DNA 序列也形成卫星 DNA,它是其他结构元件的一部分。卫星 DNA ...
Noncoding DNA refers to the portion of DNA that does not encode proteins. It was previously thought to have no function, but recent research has revealed its involvement in various cellular processes such as DNA cutting and splicing, transposon reassembly, genome rearrangements, and the production ...
Exons hold the instructions for making proteins (the coding region), whereas introns are interspacing non-coding DNA, which is removed in later processing (transcription) but can hold regulatory units controlling gene function. Genomic medicine for inherited eye disease: This article provides a guide...
CompositionComposed of exons (coding sequences) and introns (DNA regions with no known function)Composed of regulatory elements, repeating sequences, pseudogenes, introns, and telomeres SynthesisUndergoes transcription to synthesize mRNAsUndergoes transcription to synthesize regulatory RNAs including...
the mechanism through which 3′UTRs exert their non-coding functionin transfalls within the concept of mRNAs as sponges for miRNAs, i.e., as ceRNAs. Hundreds of papers about this topic have been published in the last decade, most of which are in the context of cancer. Indeed, when 3′...
Messenger RNAs transcribed from olfactory-receptor genes may have non-coding functions that include recruitment of transcriptional enhancers and inhibition of potentially thousands of competing alleles to ensure stable transcription of a single allele. Ariel D. Pourmorady , Elizaveta V. Bashkirova & Stav...
Long non-coding RNAs (lncRNAs) can often function in the regulation of gene expression during development; however, their generality as essential regulators in developmental processes and organismal phenotypes remains unclear. Here, we performed a tailored investigation of lncRNA expression and function ...
DNA:RNA immunoprecipitation DRIVE: DNA:RNA in vitro enrichment GRID-seq: Global RNA interactions with DNA by deep sequencing GRO-seq: Global run-on sequencing HTS: High-throughput sequencing lincRNA: Long intergenic noncoding RNAs lncRNA:
Although long non-coding RNAs (lncRNAs) and mRNAs share many common features, several types of lncRNAs are distinguished from mRNAs by unique features of biogenesis, form and function. lncRNAs exhibit more highly specific expression patterns than mRNAs. ...