肿瘤诱导KLRG1表达升高,使Treg细胞抑制功能增强,NK、Teff细胞毒性减弱,因此,在肿瘤治疗中同时靶向Teff及NK、Treg细胞中的KLRG1可能带来更好的治疗效果。 杀伤细胞凝集素样受体G1(killer cell lectin-like receptor G1 ,KLRG1)是一种NK、T细胞衰老和耗竭时表达升高的共抑制受体,通过抑制AKT磷酸化,可导致NK、T细胞增殖...
cad, recruiting SHIP-1 and SHP-2, inhibiting NK cell and T-cell function, and inducing cardiac endothelial cell proliferation and angiogenesis [62,63]. Moreover, KLRG1 can also cause functional depletion of NK cells by binding to soluble N-cad released by circulating tumor cells in a nonconta...
Killer cell lectin-like receptor G1 (KLRG1) has traditionally been regarded as an inhibitory receptor of T cell exhaustion in chronic infection and inflammation. However, its exact role in hepatitis B virus (HBV) infection remains elusive. CD8 T cells from 190 patie...
Killer cell lectin-like receptor subfamily G, member1-KLRG1属于杀伤细胞凝集素样受体,是NK 优先表达的一类跨膜蛋白,胞内含有ITIM基序,是淋巴细胞共抑制或免疫检查点受体,主要表达于晚期分化效应和效应记忆CD8+ T细胞和NK细胞。 KLRG1 包涵体肌炎(IBM)是一种缓慢进展的骨骼肌疾病,具有独特的临床和病理特征(包括手指...
杀伤细胞凝集素样受体g1( killer cell lectin-like receptor g1 , klrg1 )是一种nk、t细胞衰老和耗竭时表达升高的共抑制受体,通过抑制akt磷酸化,可导致nk、t细胞增殖功能障碍和效应功能降低。 klrg1 + treg klrg1 + treg为诱导型treg细胞亚群 ,由胸腺外组织驻留treg细胞受...
Abcuro成立于2016年,总部位于马塞诸塞州,曾于2018年完成800万美元的A轮融资,基础知识产权来自布列根和妇女医院Steven A Greenberg博士实验室。公司主要的候选疗法是KLRG1抗体,该抗体可靶向效应细胞毒性T细胞和NK细胞表达的受体KLRG1 (killer cell lectin-likereceptor G1)。
Killer cell lectin-like receptor G1 (KLRG1) is an immune checkpoint receptor expressed predominantly in NK and T-cell subsets that downregulates the activation and proliferation of immune cells and participates in cell-mediated immune responses. Accumula
Killer cell lectin‐like receptor G1αE (CD103)E‐cadherin. CD8+ T cellTGF‐βThe inhibitory receptor KLRG1 and the integrin 伪E (CD103) are expressed by CD8(+) T cells and both are specific for E-cadherin. However, KLRG1 ligation by E-cadherin inhibits effector T-cell function, ...
Beyersdorf NB, Ding X, Karp K, Hanke T. Expression of inhibitory "killer cell lectin-like receptor G1" identifies unique subpopulations of effector and memory CD8T cells.Eur J Immunol. 2001; 31(12):3443-3452. Henson SM, Akbar AN. KLRG1--more than a marker for T cell senescence.Age ...
KLRG1 was also dispensable for normal CD8 T-cell differentiation and function after viral infections. Thus, KLRG1 is a marker for distinct NK and T-cell differentiation stages but it does not play a deterministic role in the generation and functional characteristics of these ly...