NK 细胞免疫抑制性受体-KLRG1 Killer cell lectin-like receptor subfamily G, member1-KLRG1属于杀伤细胞凝集素样受体,是NK 优先表达的一类跨膜蛋白,胞内含有ITIM基序,是淋巴细胞共抑制或免疫检查点受体,主要表达于晚期分化效应和效应记忆CD8+ T细胞和NK细胞。 KLRG1 包涵体肌炎(IBM)是一种缓慢进展的骨骼肌疾病,具有...
KLRG1+Treg细胞凋亡增加 Eur J Immunol. 2013 May;43(5):1195-207. 所以,靶向KLRG1不仅可以作为直接针对NK、T细胞免疫细胞耗竭的肿瘤治疗策略,而且对于KLRG1+Treg细胞功能的调控也可以很好地辅助ICI治疗。 KLRG1+CD8+T细胞 KLRG1作为免疫检查点受体,相比PD-1与CTLA-4,在CD8+T细胞和NK细胞上表达更高,而且与CD8+T细...
所以,靶向KLRG1不仅可以作为直接针对NK、T细胞免疫细胞耗竭的肿瘤治疗策略,而且对于KLRG1 + Treg细胞功能的调控也可以很好地辅助ICI治疗。 KLRG1+CD8+T细胞 KLRG1作为免疫检查点受体,相比PD-1与CTLA-4,在CD8+T细胞和NK细胞上表达更高,而且与CD8+T细胞功能高度相关。 Abcuro是最早进行KLRG1靶点开发的Biotech公司(2021年获...
Human KLRG1检测金标准 目前已经证实,NK细胞和CD8+T细胞拥有许多共同的抑制性受体,这些抑制性受体在他们的功能和表型特征分析中起着十分重要的作用。KLRG1(killer cell lectin-like receptor G1),杀伤性细胞凝集素样受体G1,就是其中一种抑制分子。目前研究发现,KLRG1在NK细胞和部分CD8+T细胞,以及一些肥大细胞和嗜碱性...
Killer cell lectin-like receptor G1 (KLRG1) is expressed as a homodimer,composed of glycosylated 30-38 kDa subunits, on natural killer (NK) cellsand activated CD8 T cells. KLRG1 expression is tightly regulated and isinduced through different molecular mechanisms in varying subsets ofimmune-...
人KLRG1在大量NK细胞、淋巴因子激活杀伤(LAK)细胞和贴壁LAK(A-LAK)细胞亚群,以及在CD8+和CD4+T淋巴细胞亚群上表达,但不在肥大细胞上表达。1BD开发了一种靶向人KLRG1的新型重组单克隆抗体(rMab),它可改善分离并有可能帮助区分表达KLRG1的新型免疫细胞亚群。
KLRG1 is an inhibitory receptor that is expressed on natural killer (NK) cells and certain T cells. NK cells are involved in the lysis of tumor cells and virus-infected cells, and mediate humoral and cell-mediated immune responses. 仅用于科研。不用于诊断过程。未经明确授权不得转售。 This is ...
Killer cell lectin-like receptor G1 (KLRG1) is an immune checkpoint receptor expressed predominantly in NK and T-cell subsets that downregulates the activation and proliferation of immune cells and participates in cell-mediated immune responses. Accumula
The killer cell lectin-like receptor G1 (KLRG1) is a unique inhibitory receptor expressed on a phenotypically mature subset of resting NK cells as well as effector memory CD8T cells. KLRG1 is a C-type lectin inhibitory receptor that contains an immunoreceptor tyrosine-based inhibitory motif (...
KLRG1 is a newly identified member of the KLR family and is expressed in NK cells and a subset of T cells. Although all of them are highly expressed in CD28−CD8 T cells, the patterns of their expression differ. A down-regulation of expression from naı¨ve to memory (CD28+) is ...