KLRG1+Treg细胞凋亡增加 Eur J Immunol. 2013 May;43(5):1195-207. 所以,靶向KLRG1不仅可以作为直接针对NK、T细胞免疫细胞耗竭的肿瘤治疗策略,而且对于KLRG1+Treg细胞功能的调控也可以很好地辅助ICI治疗。 KLRG1+CD8+T细胞 KLRG1作为免疫检查点受体,相比PD-1与CTLA-4,在CD8+T细胞和NK细胞上表达更高,而且与CD8+T细...
所以,靶向KLRG1不仅可以作为直接针对NK、T细胞免疫细胞耗竭的肿瘤治疗策略,而且对于KLRG1 + Treg细胞功能的调控也可以很好地辅助ICI治疗。 KLRG1+CD8+T细胞 KLRG1作为免疫检查点受体,相比PD-1与CTLA-4,在CD8+T细胞和NK细胞上表达更高,而且与CD8+T细胞功能高度相关。 Abcuro是最早进行KLRG1靶点开发的Biotech公司(2021年获...
2021年另一篇文献中,对肿瘤小鼠模型使用klrg1/抗pd-1抗体联合治疗,比单一药物拥有更好的疗效,能够使肿瘤生长和转移减少,且增加了nk、t细胞数量。 oncoimmunology. 2021 jun 15;10(1):1933808. 基于klrg1对teff细胞和nk细胞的抑制作用, abcuro公司开始进行klrg1单抗(abc015)开...
Human KLRG1检测金标准 目前已经证实,NK细胞和CD8+T细胞拥有许多共同的抑制性受体,这些抑制性受体在他们的功能和表型特征分析中起着十分重要的作用。KLRG1(killer cell lectin-like receptor G1),杀伤性细胞凝集素样受体G1,就是其中一种抑制分子。目前研究发现,KLRG1在NK细胞和部分CD8+T细胞,以及一些肥大细胞和嗜碱性...
Killer cell lectin-like receptor G1 (KLRG1) is expressed as a homodimer,composed of glycosylated 30-38 kDa subunits, on natural killer (NK) cellsand activated CD8 T cells. KLRG1 expression is tightly regulated and isinduced through different molecular mechanisms in varying subsets ofimmune-...
The killer cell lectin-like receptor G1 (KLRG1) is a unique inhibitory receptor expressed on a phenotypically mature subset of resting NK cells as well as effector memory CD8T cells. KLRG1 is a C-type lectin inhibitory receptor that contains an immunoreceptor tyrosine-based inhibitory motif (...
KLRG1 is a newly identified member of the KLR family and is expressed in NK cells and a subset of T cells. Although all of them are highly expressed in CD28−CD8 T cells, the patterns of their expression differ. A down-regulation of expression from naı¨ve to memory (CD28+) is ...
流式细胞分析 (Flow) 0.1-0.2 µg / 1x10^6 cells - 产品规格 宿主/亚型 Syrian hamster / IgG 分类 Monoclonal 类型 Antibody 克隆号 2F1 抗原 Activated NK (A-LAK) cells from B6 (H-2b) mice. 偶联物 PE Request custom conjugation
cells; however, the expression of mouse KLRG1/MAFA using 2F1 has not been detected on the surface of mouse mast cell lines, bone marrow-derived mast cells, or peritoneal mast cells. This antigen is expressed on approximately one-third of mouse NK cells and a subset of T cells. MHC class...
具有外源性dna的细胞可以是各种细胞,例如,体细胞、免疫细胞(例如t细胞、b细胞、nk细胞、抗原呈递细胞、巨噬细胞、树突状细胞)、生殖细胞、囊胚或肿瘤细胞。在一些实施例中,提供了一种基因修饰的非人动物,所述非人动物包含被修饰的内源klrg1基因座,该内源klrg1基因座包含外源序列(如,人源序列),例如,用一个或多个人...