Rattus norvegicus killer cell lectin-like receptor subfamily C,member 1 (Klrc1), mRNA. 基因ID: 29683 序列: atgagtaatgatcgagtcacctatgcagaactgaatgtggccaagaactcaaggtaccagcacaacaaaccaaggggcagtcgcagctccatttcagtaatagagcaggaaatcgtttatgcggatttcagctttaaaaatccttctcaagagcagacccggatctgcagggattgc...
DNA描述 Homo sapiens killer cell lectin like receptor C1 (KLRC1), transcript variant 1, mRNA DNA大小: 1436 bp DNA编码区: atggataaccaaggagtaatctactcagacctgaatctgcccccaaacccaaagaggcag caacgaaaacctaaaggcaataaaaactccattttagcaactgaacaggaaataacctat gcggaattaaaccttcaaaaagcttctcaggattttcaagggaatgacaaaa...
NKG2A inhibits invariant NKT cell activation in hepatic injury. Activation of invariant NKT (iNKT) cells in the liver is generally regarded as the critical step for Con A-induced hepatitis, and the role of NK cell recep... T Kawamura,K Takeda,H Kaneda,... - 《Journal of Immunology》 被...
The killer cell lectin-like receptor family is a group of transmembrane proteins preferentially expressed in NK cells. Members of this proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. NKG2 is expressed only in NK-cells, but not in T-...
按照Human T Cell Nucleofector Kit(Lonza)的操作手册,将载有sgRNA寡聚核苷酸的质粒与序列为SEQ ID NO.76的Cas9质粒(结构如图2所示)混匀,共转染细胞。 5.用T7EN1酶切检测和流式细胞术检测确认NKG2A/KLRC1基因已经被敲除。 更进一步的,同时利用一对相邻(在人NKG2A/KLRC1基因上的靶向起始位点相距0-200bp)的sgR...
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按照humantcellnucleofectorkit(lonza)的操作手册,将载有sgrna寡聚核苷酸的质粒与序列为seqidno.76的cas9质粒(结构如图2所示)混匀,共转染细胞。 5.用t7en1酶切检测和流式细胞术检测确认nkg2a/klrc1基因已经被敲除。 更进一步的,同时利用一对相邻(在人nkg2a/klrc1基因上的靶向起始位点相距0-200bp)的sgrna可以显著...
(aa 94-244), mouse NKG2A shares 71% and 41% aa sequence identity with rat and human NKG2A, respectively. An isoform lacking aa 98-114 has been described. NKG2A associates with CD94 and is coexpressed on NK cells and some activated T cell populations. The NKG2A/CD94 complex delivers ...
NKG2A belongs to a group of natural killer (NK) cell inhibitor receptors (IRs) which includes killer immunoglobulin receptors (KIRs), lymphocyte activation gene-3 (LAG-3), T cell immunoreceptor with Ig and ITIM domains (TIGIT), programmed death ligand-1 (PD-1), and T cell immunoglobulin ...
NK group 2 member A (NKG2A), also known as killer lectin like receptor c1 (KLRC1) and CD159a, is a ~38 kDa type II transmembrane protein belonging to the C-type lectin superfamily and plays a role in suppression of cytotoxic CD8+ T cell activity and functions as an immune checkpoint ...