overexpression and knockdown experiments were performed in a mouse dental papilla cell line(iMDP-3).Klf6 functioned as a promoter of odontoblastic differentiation and inhibited the proliferation and cell cycle progression of i MDP-3 through p21 upregulation.Dual-luciferase reporter assay and chromatin ...
p53 is a critical tumor suppressor, which transactivates multiple target genes involved in controlling cell cycle arrest, apoptosis, senescence, DNA damage repair, and cell metabolism1. It has been documented that more than 50% human tumors bear p53 gene mutations, of which missense mutations accou...
including the kidney, to maintain homeostasis as well as in development and in disease8. Among the 17 members of the KLF family, Krüppel-like factor 6 (KLF6) is an early-inducible responsive gene expressed with cell-specific
TGFβ antagonizes this process by preventing cells from exiting the cell cycle hence maintaining myoblasts in a proliferative state. TGFβ ligands bind to a type II receptor which becomes activated and autophosphorylated [16]. The activated type II receptor can then phosphorylate and activate a ...
overexpression and knockdown experiments were performed in a mouse dental papilla cell line(iMDP-3).Klf6 functioned as a promoter of odontoblastic differentiation and inhibited the proliferation and cell cycle progression of i MDP-3 through p21 upregulation.Dual-luciferase reporter assay and chromatin ...
KRPPEL-LIKE TRANSCRIPTION FACTOR 6 (KLF6) OVEREXPRESSION INDUCES CELL CYCLE ARREST AND FUSION OF BEWO CELLSdoi:10.1016/j.placenta.2019.06.212Andrea Lis MirandaLucille KourdovaAna Cristina RaccaMaría Laura RojasMariano Matías Cruz del PuertoSusana Genti-Raimondi...
Thus, we hypothesize that the tumor suppressor protein KLF6 has a role in cell cycle control, the outcome of which is the inhibition of cell proliferation.Mount Sinai School of Medicine of New York University.Benzeno, Sharon.Mount Sinai School of Medicine of New York University....
cell cyclecisplatin resistanceE2F transcription factor 1(E2F1)Kruppel-like factor 6(KLF6)lung adenocarcinomameiotic nuclear divisions 1(MND1)positive feedback loopBackground:Considering the increase in the proportion of lung adenocarcinoma(LUAD)cases among all lung cancers and its considerable contribution...
Cell apoptosis and cell cycle were investigated by flow cytometry. Enzyme-linked immunosorbent assays were conducted to detect IL-1[beta], TNF-[alpha] and IL-6 levels. Fe2+ colorimetric assay kit was used to detect Fe2+ level. MDA Content Assay Kit was used to detect MDA level. Cellular ...
Gene ontology enrichment analysis indicated that the function of the magenta module primarily focused on transcription regulation, cell cycle control, and apoptosis modulation. Integration of the WGCN with the protein-protein interaction network identified five candidate genes. These five genes were ...