2025年2月14日,来自耶鲁大学的Nikhil S. Joshi团队在Science发表了标题为“KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection.”的研究成果,发现单细胞CRISPR筛选(PerturbSEQ)揭示了转录因子KLF2在维持CD8+ T细胞效应谱系稳定性和抑制T细胞耗竭中的关键作用,为免疫治疗提...
Also, CD4+T cells express lower levels of S1pr1 and Klf2 than WT mice, which may influence pathogenic CD4+T-cell egress from the spleen and migration to the CNS. Moreover, the single-cell ATAC sequence and ChIP assay reveal that the transcription factor Klf2 is enriched at the S1pr1 ...
Kruppel-like factors (KLFs) are a family of broadly expressed zinc finger transcription factors. KLF2 regulates T-cell trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1; MIM 601974) and the selectin CD62L (SELL; MIM 153240) (summary by Weinreich et al., 2009 [...
异常修复是肺纤维化发病机制的基础,而将纤维化转化为正常再生的有效策略却很少。 2024年10月7日,河南师范大学余国营及王兰共同通讯在Nature Communications在线发表题为“TRβ activation confers AT2-to-AT1 cell differentiation and anti...
KLF2 regulates T-cell trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1; MIM 601974) and the selectin CD62L (SELL; MIM 153240) (summary by Weinreich et al., 2009 [PubMed 19592277]).[supplied by OMIM, Feb 2011] [中文简述(自动翻译):] Kruppel样因子(KLFs)是...
Lineage-specific deletion of KLF2 resulted in fewer naive T cells in the blood and secondary lymphoid organs, whereas it expanded naive T cell numbers in nonlymphoid tissues; these effects were associated with altered expression of inflammatory chemokine receptors on naive T cells. KLF2 repressed ...
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many of which are involved in cell migration. Human KLF2 is 355 amino acids (aa) in length. It contains an activation domain (aa 1-110), an inhibitory domain (aa 111-267), and three C2H2-type zinc-finger regions (aa 272-354). There is one potential splice form that shows a prematur...
ʌ摘要ɔ 肺K r üp p e l 样转录因子(K L F 2/L K L F )是锌指K r üp p e l 样转录因子家族成员之一,由于最初发现K L F 2主要在肺内表达因此也称为L K L F ㊂研究表明K L F 2在肺与血管的发育,T 细胞静止㊁活化和迁移中起重要作用㊂近年的研究表明,K L F 2对许多疾病的发生...
KLF2 regulates T-cell trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1; MIM 601974) and the selectin CD62L (SELL; MIM 153240) (summary by Weinreich et al., 2009 [PubMed 19592277]).[supplied by OMIM, Feb 2011] Size:50ul Concentration:1mg/ml Applications:WB(1...