Cellularly, TRβ activation enhances alveolar type-2 (AT2) cell differentiation into AT1 cell and constrains AT2 cell hyperplasia. Molecularly, TRβ activation directly regulates the expression of KLF2 and CEBPA, both of which further synergistically drive the differentiation program of AT1 cells and ...
Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of mortality worldwide. Laminar shear stress from blood flow, sensed by vascular endothelial cells, protects from ASCVD by upregulating the transcription factors KLF2 and KLF4, which ind
many of which are involved in cell migration. Human KLF2 is 355 amino acids (aa) in length. It contains an activation domain (aa 1-110), an inhibitory domain (aa 111-267), and three C2H2-type zinc-finger regions (aa 272-354). There is one potential splice form that shows a prematur...
Trademarks and Patents Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc. All other trademarks are the property of their respective owners. Visitcellsignal.com/trademarksfor more information. 限制使用 除非CST 的合法授书代表以书面形式书行明确同意,否书以下条款适用...
METHODS: Apoptosis, proliferation, insulin secretion and cell survival rate were detected to evaluate the function of miRNA-92a. RESULTS: we found that miRNA-92a could inhibit apoptosis induced by high-glucose environment and increase the insulin secretion and proliferation. Moreover, we identify the...
ID 100163 Poster Board 365 Objective:Examine the ability of EA to promote osteoblastic differentiation in dental pulp-derived stem cells, elucidate the in-depth regulatory mechanisms underlying EA-induced osteogenic differentiation, and investigate the specific role of KLF2 in this osteogenesis process. ...
Mouse endothelial cell isolation Mouse endothelial cells were isolated as described [28, 29]. In brief, the peripheral lung tissues (about 1.0 mm on the edge of the lung tissue) encompassing microvessels were sheared and minced. The tissues were individually digested at 37 °C for 30 min in...
The Nrf2 inhibitor ML385 and HO-1 siRNA were used to elucidate the mechanism of activation. The results show that overexpression of KLF2 increased the cell viability, reduced the lactate dehydrogenase leakage rate, downregulated the generation of O2•− and ONOO−, and increased NO levels ...
The cell viability was determined by MTT. Data are expressed as means ± SD (n = 6). ##p < 0.01 vs. group without YQHX treatment. (b) HUVECs were pretreated with YQHX (0.25 and 1.25 mg/ml) or ST (3 μM) for 3 h prior to LPS treatment (25 μg/ml) for 12...
Formalin-fixed and paraffin embedded human colon carcinoma labeled with Rabbit Anti KLF4 Polyclonal Antibody, Unconjugated (bs-1064R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.View more 产品信息 应用 建议稀释比 ...