鉴于KEAP1和NRF2在癌症中经常发生突变,探索TFEB/TFE3在NRF2驱动的癌症中的作用将是有趣的。 参考文献:Ong, A. J. S., Bladen, C. E., Tigani, T. A., Karamalakis, A. P., Evason, K. J., Brown, K. K., & Cox, A. G. (2023). The KEAP1-NRF2 pathway regulates TFEB/TFE3-dependent...
2022年7月5日,国际权威生物学杂志Oxidative Medicine and Cellular Longevity (IF=7.31)发表了复旦大学附属金山医院肿瘤科乔田奎教授团队的最新研究成果“Activation of the P62-Keap1-NRF2 Pathway Protects against Ferroptosis in Radiation-...
我们继续来讲这篇Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells 上游他们基本上就做到了这里,那接下来,他们做了铁死亡时NRF2激活后的一些下游实验。 他们发现,Erastin和Sorafenib...
Keap1-Nrf2 Inhibitors on signaling pathway are available at Adooq Bioscience. Check Keap1-Nrf2 pathway , inhibitors reviews and assay information.
In this chapter, we highlight the relationship between lung cancers and Keap1-Nrf2-ARE signaling with an emphasis on the dysregulation of Keap1-Nrf2 signaling, Keap1 and Nrf2 mutations, microRNAs in Keap1-Nrf2 signaling, smoking and Nrf2 activation in lung cancer, and Keap1-Nrf2 pathway as ...
ObjectiveTo explore the effects of red LED light mediated by the Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2/heme oxygenase-1 (KEAP1-NRF2/HO-1) pathway on osteogenic differentiation and oxidative stress damage of human periodontal ligament stem cells (hPDLSCs)...
2022年8月11日,河南农业大学食品科学与技术学院李宁教授在Frontiers in Nutrition杂志上发表了题为“Alleviating effects of pea peptide on oxidative stress injury induced by lead in PC12 cells via Keap1/Nrf2/TXNIP signaling pathway”的研究性文章。该文章指出,当大鼠嗜铬细胞瘤细胞系PC12细胞暴露于铅时,会产...
et al. Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution. Genes Cells. 2011; 16(2): 123-140.8. Zimta AA, et al. The Role of Nrf2 Activity in Cancer Development and Progression. Cancers (Basel). 2019; 11(11): 1755.9. Wu S, et al. Nrf2 in ...
[关键词] Kelch样环氧氯丙烷相关蛋白-1;核因子E2相关因子2;抗氧化反应元件;氧化应激;调控机制[中图分类号] R34-33 [文献标志码] A [文章编号] 1674-0440(2016)01-0146-08DOI:10.13220/j.cnki.jipr.2016.01.022Anti-oxidative stress actions and regulation mechanisms ofKeap1-Nrf2/ARE signal pathwayHU ...
Fig 1 Keap1-Nrf2-ARE signaling pathway 在生理状态下,Nrf2参与调节氧化还原平衡、细胞的增殖、凋亡过程、炎症过程、物质代谢、蛋白质的折叠等。众所周知,Nrf2是机体氧化还原反应的主要调节器,它可以对多种抗氧化基因的表达产生促进作用,如谷胱甘肽过氧化物酶(glutathione peroxidase, GPx)、醌氧化还原酶1[NAD(P)H...