接下来,利用肝细胞报告细胞系(Tg(lf:NLS-mcherry))特异性检测肝细胞中的Nrf2活性。虽然crkeap1a/b幼虫的肝脏体积和肝细胞数量没有变化,但肝细胞中Nrf2活性显著增加(图2B,C和图S2A,B)。流式细胞术分析证实,从crkeap1a/b幼虫分离的肝细胞中Nrf2报告细胞活性升高(图2D)。组织学评估显示,肝细胞核的窦状窦变宽...
2022年7月5日,国际权威生物学杂志Oxidative Medicine and Cellular Longevity (IF=7.31)发表了复旦大学附属金山医院肿瘤科乔田奎教授团队的最新研究成果“Activation of the P62-Keap1-NRF2 Pathway Protects against Ferroptosis in Radiation-...
1. W. L. Wu, T. Papagiannakopoulos, The Pleiotropic Role of the KEAP1/NRF2 Pathway in Cancer.Annual Review of Cancer Biology4, 413-435 (2020). 2. G. M. DeNicolaet al., Oncogene-induced Nrf2 transcription promotes ...
The Nrf2-Keap1 [Nuclear factor E2-related factor 2-Kelch like ECH-associated protein 1] pathway is the main regulator of cytoprotective responses to electrophilic and oxidative insults. Nrf2 regulates the expression of detoxifying enzymes by recognizing the human antioxidant response element (ARE) ...
et al. Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution. Genes Cells. 2011; 16(2): 123-140.8. Zimta AA, et al. The Role of Nrf2 Activity in Cancer Development and Progression. Cancers (Basel). 2019; 11(11): 1755.9. Wu S, et al. Nrf2 in ...
Key words: Diabetes; Skin ulcer; Keap1/ Nrf2 pathway; Badu Shengji powder 糖尿病皮肤溃疡属中医消渴病变证之一,中医认为其主要病机为正气亏虚,伏毒内侵,遇感诱发 [1] 。祛腐生肌是治疗皮肤溃疡的重要方法。 拔毒生肌散是临床祛腐生肌的经典药物,源于清代名医赵廷海所著《救伤秘旨》,“凡破伤不论新久...
Keap1-Nrf2 Inhibitors on signaling pathway are available at Adooq Bioscience. Check Keap1-Nrf2 pathway , inhibitors reviews and assay information.
我们假设PFOA通过抑制Keap1/Nrf2通路诱导心脏缺陷,从而导致心肌细胞的氧化损伤。在本研究中,暴露于PFOA的斑马鱼胚胎出现了显著的心脏畸形和功能障碍,表现为过量的活性氧(ROS)和丙二醛(MDA)产生,以及超氧化物歧化酶(SOD)、过氧化氢酶(CAT)和谷胱甘肽过氧化物酶(GSH-Px)活性降低。此外,心脏发育相关关键基因(vmhc、...
The p62/KEAP1/NRF2 Pathway Antibody Sampler Kit provides an economical means of detecting the non-canonical mechanism of NRF2 activation involving autophagy. The kit includes enough antibodies to perform two western blot experiments with each primary antibody. Background The cap ’n’ collar (CN...
2022年8月11日,河南农业大学食品科学与技术学院李宁教授在Frontiers in Nutrition杂志上发表了题为“Alleviating effects of pea peptide on oxidative stress injury induced by lead in PC12 cells via Keap1/Nrf2/TXNIP signaling pathway”的研究性文章。该文章指出,当大鼠嗜铬细胞瘤细胞系PC12细胞暴露于铅时,会产...