The Nrf2-Keap1-ARE Signaling Pathway: The Regulation and Dual Function of Nrf2 in Cancer.The NF-E2-related factor-2 (Nrf2) is a transcription factor that is ubiquitously expressed at low levels in all human organs. As Nrf2 regulates a major cellular defense mechanism, tight regulation is ...
[41]Fu K, Wang Z, Cao R. Berberine attenuates the inflammatory response by activating the Keap1/Nrf2 signaling pathway in bovine endometrial epithelial cells[J]. Int Immunopharmacol, 2021, 96: 107738. DOI: 10.1016/j.intimp.2021....
A 文章编号:1674 - 5515(2022)11 - 2437 - 07 DOI: 10.7501/j.issn.1674-5515.2022.11.004 Effects of lycopene on cognitive impairment and oxidative stress response in schizophrenia rats by regulating Keap1/Nrf2/ARE signaling pathway ZHANG Xiao-li1, DONG Jiao1, NING Qiu-fen2, WANG Xin-you1 1...
Objective To investigate the mechanisms of ATR-induced dopaminergic toxicity by microglia activation and the response of the Keap1/ Nrf2- ARE signaling pathway. Methods Wistar rats were treated with 50, 100 and 200mg/kg ATR and BV-2 microglia cells were treated with 50, 100渭M ATR or 100ng...
//引用本文张永波, 毕颖斐. 中医药通过调控Keap1/Nrf2/ARE信号通路治疗心肌肥厚的研究进展. 天津中医药大学学报, 2024, 43(2): 171-175.ZHANG Yongbo, BI Yingfei. Research progress of traditional Chinese medicine in the treatment ...
Nrf2 signaling pathway: pivotal roles in inflammation [J]. Biochim Biophys Acta Mol Basis Dis, 2017, 1863 (2): 585-597. DOI: 10.1016/j.bbadis.2016.11.005. [25] Dodson M, Castro-Portuguez R, Zhang DD. NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis [J]. ...
views the role of Keap1 / Nrf2 / ARE signaling pathway in central nervous system diseases. 【Key words】 Signal transduction;Nervous system diseases;Oxidative stress 氧化应激广泛参与神经系统的病理生 理变化,脑缺血再灌注损伤是氧化应激的 急性表现,慢性氧化应激亦是神经系统退 行性疾病发生发展的重要原因...
Brain cancer is regarded as one of the most life-threatening forms of cancer worldwide. Oxidative stress acts to derange normal brain homeostasis, thus is involved in carcinogenesis in brain. The Nrf2/Keap1/ARE pathway is an important signaling cascade r
Keap1-Nrf2-ARE signaling pathway and activators in Parkinson’s disease:a review 在线阅读 免费下载 引用 收藏 分享 摘要 Nrf2是一种转录调节因子,在协调细胞对氧化应激的反应中起着关键作用。Nrf2通过与Keap1和抗氧化反应元件(ARE)相互作用,介导细胞防御氧化应激的基因的表达,从而发挥重要抗氧化损伤作用。
pathway.Afterthesignalingpathwayisactivated,thebody'santioxidantabilitydecreased,proinflammatorycytokinesimbalanced,in flammationindexincreased.Whenthebodyislongbeinunbalancecondition,thenumberofabnormalimmunecomplexdepositionin creased.Intheend,theresultisthatASiscausedandcardiacfunctionisdecreased. [Keywords]AnkylosingSp...