Keap1,and the target protein glutathione peroxidase1 (GPX-1) downstream of the Keap1-Nrf2/ARE pathway were detected by RT-PCR.ResultsCompared with the model control group,the levels of Upro / 24h,NAG,and KIM-1 in the urine of the model control group were significantly higher (...
Nrf2/Keap1/ARE has been reported to orchestrate downstream oxidative mechanisms, which in turn regulate several inflammatory and apoptotic pathways [3]. The Nrf2/Keap1 pathway plays a crucial role in the regulation of genes responsible for antioxidant and cytoprotective functions. Nrf2, a transcription...
1 Keap1-Nrf2/ARE信号通路的基本结构1. 1 Nrf2的结构Nrf2蛋白相对分子质量为6.6×10 4 ,位于2q31位Keap1-Nrf2/ARE信号通路的抗氧化应激作用及其调控机制胡流芳,王迎,任汝静,霍海如,孙建辉,李洪梅,朱亚英,谭余庆 *[摘要] Kelch样环氧氯丙烷相关蛋白-1(Keap1)-核因子E2相关因子2(Nrf2)/抗氧化反应元件(ARE)...
(Nrf2)和它的胞质接头蛋白Keap1是细胞抗氧化反应的中枢调节者,Nrf2通过与抗氧化反应元件(ARE)相互作用,诱导编码抗氧化蛋白和Ⅱ相解毒酶的表达,在细胞的防御保护中发挥重要作用.Keap1_Nrf2/ARE通路在抗肿瘤,抗应激,调节GSH合成,抗凋亡,抗炎症反应,神经保护等方面发挥着广泛的细胞保护功能.本文综述了Keap1_Nrf2/ARE...
The Nrf2-Keap1-ARE Signaling Pathway: The Regulation and Dual Function of Nrf2 in Cancer.The Nrf2-Keap1-ARE Signaling Pathway: The Regulation and Dual Function of Nrf2 in Cancer.The NF-E2-related factor-2 (Nrf2) is a transcription factor that is ubiquitously expressed at low levels in all...
中华危重病急救医学 2021 年 7 月第 33 卷第 7 期 Chin Crit Care Med,July 2021,Vol.33,No.7 Keap1/Nrf2/ARE 信号通路可通过调节氧化应激 缓解脓毒症过程中的细胞铁死亡 · 881 · ·综述· 李嘉柔 王洪亮 哈尔滨医科大学附属第二医院重症医学科,黑龙江哈尔滨 150086 通信作者 :王洪亮,Email :icuwang...
Keap1-Nrf2/ARE抗氧化系统与蜕膜化缺陷 1.蜕膜化缺陷导致不良妊娠结局:ESC在黄体期的蜕膜化过程构成了子宫内膜容受性的重要组成部分,是胚胎着床的先决条件。对于早期妊娠而言,适度的蜕膜化控制着内膜容受过程,并对妊娠的建立起到决定性作用,ESC分化...
(4) Bach1介导的Nrf2抑制调节溶酶体生物发生 除了NRF2调控的基因富集外,HOMER de novo基序分析发现BTB结构域和CNC同源物1 (BACH1)是crkeap1a/b幼虫中最富集的基序之一(图1C)。BACH1是一种转录抑制因子,通过与MAF识别元件(MARE)结合来调节血红素代谢。由于MARE和ARE基序的相似性,已知NRF2靶基因的一个子集受BACH...
Conclusion Lycopene can regulate the Keap1/Nrf2/ARE pathway, promote the expression of Keap1, Nrf2, and HO-1, relieve oxidative stress and ameliorate cognitive function, thereby relieving schizophrenia and improving the disease. Key words: lycopene; schizophrenia; Kelch-like epichlorohydrin-related ...
(Nrf2)和它的细胞质接头蛋白Keapl是细胞抗氧化 反应的中枢调节者.实验证明,Nrf2通过与ARE相 互作用调节编码抗氧化蛋白和Ⅱ相解毒酶的表达. 大量的研究发现Keap1,Nrf2/ARE通路在诸如抗肿 瘤,神经保护,抗炎症反应等方面具有广泛的细胞保 护功能. 1Keapl-Nri2/ARE通路的分子基础 ...