KEAP1 Knockout 293T Cell Line, Homozygous规格: 货期: 编号:MZ-3966 品牌:Mingzhoubio 活化细胞 冻存细胞 荧光标记细胞 规格: T25瓶 冻存管 加入购物车 在线咨询 收藏 商品简介 购买须知 联系我们 产品名称 KEAP1 Knockout 293T Cell Line, Homozygous 商品货号 MZ-3966 基因名称 KEAP1 基因物种 Human...
A homozygous Keap1-knockout human embryonic stem cell line generated using CRISPR/Cas9 mediates gene targetingdoi:10.1016/j.scr.2016.12.028So Jung KimOmer HabibJin Soo KimJung Hyun Kim
Western blot analyses of total cell lysates of KEAP1-knockout MEF cells rescued with either wild-type (WT) (A,B), single cysteine mutant C151S (A), double cysteine mutant C273W/C288E (B), or triple cysteine mutant C151S/C273W/C288E (A and B) of mouse N-terminally tagged HA-...
5b). In line with the NRF2 expression levels, APAP-induced liver damage as indicated by the serum ALT and AST levels, was much worse in Nrf2-depeleted wildtype animals than those in the Usp25 knockout controls (Fig. 5c). The liver damage was also worse in Usp25−/− animals ...
Our first task was therefore to find out which form of PGAM5 interacts with KEAP1. We immunoprecipitated KEAP1 and identified co-immunoprecipitating PGAM5 forms. Fig. 5A shows that while both the full-length and cleaved forms of PGAM5 were present in the total cell lysate, only the full-...
Generation of a Nrf2 homozygous knockout human embryonic stem cell line using CRISPR/Cas9 Stem Cell Res., 19 (2017), pp. 46-48, 10.1016/j.scr.2016.12.027 View PDFView articleGoogle Scholar [120] R. Erkens, T. Suvorava, T.R. Sutton, B.O. Fernandez, M. Mikus-Lelinska, F. Barbar...
Knockout; LDH: Lactate dehydrogenase; miR-941: MicroRNA-941; miRNA: MicroRNA; Mito-IP: Mitochondrial immunoprecipitation; mPTP: Mitochondria permeability transition pore; ncRNAs: Non-coding RNAs; NQO1: NAD(P)H:quinone oxidoreductase 1; Nrf2: Nuclear-factor-E2-related factor 2; OD: Optic density...
The development of Nrf2 knockout mice has pro... TW Kensler,N Wakabayashi,S Biswal - 《Annu Rev Pharmacol Toxicol》 被引量: 2526发表: 2013年 Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer Background: Nuclear factor erythroid-2 related factor 2 (NRF2) is a redox-...
(green box) used for the genomic Southern analyses are also indicated with the sizes of the predicted fragments. b. Genomic Southern blot analyses of the two independent ES cell clones and heterozygous and homozygousKeap1knockout mice. Top and bottom panels show detection by the 5'- and 3'-...
[12]. The overexpression of Nrf2 or Nrf2 activators inhibited osteoclastogenesis, whereas the pharmacological inhibition of Nrf2 or knockout of Nrf2 induces this process [10,13]. Inhibition of Keap1-Nrf2 PPI was discovered as a new approach to regulate oxidative stress and prevent or treat ...