FAN1 knockout (neuronal data): Data consisted of five lines of N1-FAN1+/+ and four lines of N1-FAN1−/−. A separate, independent well was taken from each line at each time point. So, observations are correlated only through shared line, not through shared well. ...
53]. We found that FAN1KO hRTECs exhibited a decline in oxidative phosphorylation and increased glycolysis when cultured under normal cell culture conditions at atmospheric oxygen levels, suggesting that FAN1 cells have enhanced sensitivity to oxidative stress. Indeed, exposure of FAN1 knockout RTECs...