Studies of hypogonadal mice with POA grafts demonstrate that distinct components of reproductive function are dissociable: hosts may demonstrate reflex but not spontaneous ovulation; others may show positive but not negative feedback. Activation of grafted GnRH cells in response to sensory input to the...
In addition to being expressed in red cells, all major red cell membrane proteins are also expressed in cells of various tissues. The potential use of knockout mice to decipher the biological functions of red cell membrane proteins in non-erythroid cells is also explored....
Comprehensive behavioral analyses of transgenic and knockout mice have successfully identified the functional roles of many genes in the brain. Over the pa... J Crawley - 《Neuron》 被引量: 581发表: 2008年 Phenotypic and Biochemical Analyses of BACE1- and BACE2-deficient Mice Goodyear, the worl...
In turn, recent findings from studies of knockout mice and functional studies have confirmed that HAMP plays a central role in mobilization of iron, shown that HFE, TFR2 and HJV modulate HAMP production according to the body's iron status, and demonstrated that HAMP negatively regulates cellul...
AIP mutations are almost always inherited from one parent; the penetrance of these mutations requires further evaluation, but seems to be very low The presence of germline MEN1 mutations should be considered a possibility in very young patients with isolated sporadic pituitary adenomas when AIP mutati...
been confined to adipocytes, HIF can be expressed in many types of cells. To dissect the role of HIF in specific types of cells during diet-induced obesity, researchers have generated tissue-specific knockout (KO) mice targeting HIF pathways, and many studies have commonly revealed that intact...
production of T helper (Th) 2-related cytokines and a compensatory decrease in the expression of naive cell- and Th1-related cytokines (McElligott et al. 1997). Irf2 knockout mice show a defect in Th1 cell development, impairment of natural killer cells (Lohoff et al. 2000),and spon[...
cells, such as those associated with glucose, lipids, and amino acids (AAs), are altered to support cell survival and growth [2]. The mechanism of metabolic reprogramming encompasses four main facets. The first is the enhanced Warburg effect of glycolysis, where tumor cells shift their primary...
aIL-22 knockout mice exhibit impaired unrecovery from DSS-induced acute colonic injury. Administration of neutralizing anti-IL-22 antibodies also delays the recovery in WT mice. No recovery is observed in IL-22-deficient and RAG1-deficient double knockout mice lacking both T and B cells IL-22...
It has been suggested that increased aromatase activity and conversion of testosterone to estrogens are activated as a feed-back mechanism which regulates adipocyte numbers. This is supported by findings in an aromatase knockout mice where estrogen plays an inhibitory role during adipogenesis to limit ...