no more putting it off. NOW is the time, so RUN and make it happen, even in the face of discouragement by others who may say what you seek to accomplish is impossible. Channel the energy of those nay-sayers into a “well then I’ll show you” mindset. ...
However, NHEJ is error-prone, and it usually results in insertions and deletions (indels) in the region being repaired. When indels occur within the coding region of a gene and result in a frameshift mutation, the gene becomes non-functional. This is known as a gene knockout (KO). ...
In the 10 years since the first knockout of the mouse p53 tumor suppressor gene (designated Trp53) was published, much has been learned about the contribution of p53 to biology and tumor suppression in the breast through the use of p53 transgenic and knockout mice. The original mice ...
The most popular and simple application is spot spraying or weeding with bolt on modules that use image capture of weed species and deploy the chemical or mechanical knockout system according to the image and location of target. The difficulties and potential for developing better and faster system...
Importantly, we must note that certain observations, such as delayed amyloid pathology in mice expressing any h-apoE isoform compared to APOE knockout (KO) mice described in Section 2, support the hypothesis that apoE4 is a loss of positive function; conversely, other observations, such as ...
Why is it so hard for you to keep a secret? Hard Metaphorically hard; A hard fate Took a hard look A hard bargainer A hard climb Hard Not yielding to pressure or easily penetrated; Hard as rock Hard Very strong or vigorous; Strong winds A hard left to the chin A knockout punch A...
The sorting strategy is shown in Supplementary Figure S3. Data processing and analysis were carried out using the 'flowCore' package (Hahne et al., 2009) of the R BioConductor gentamicin-resistance cassette via homologous recombination. Integration of the knockout cassette at the luxI1 locus was...
Alpha-tocopherol protects against oxidative stress in the fragile X knockout mouse: An experimental therapeutic approach for the Fmr1 deficiency. Neuropsychopharmacology 2009, 34, 1011–1026. [CrossRef] [PubMed] 53. Nur Azlina, M.F.; Nafeeza, M.I. Tocotrienol and alpha-tocopherol reduce ...
Despite progress in understanding the pathogenesis of atherosclerosis, the development of effective therapeutic strategies is a challenging task that requires more research to attain its full potential. This review discusses current pharmacotherapy in atherosclerosis and explores the potential of some important...
RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook Wikipedia AcronymDefinition ABAEAmateur Boxing Association of England(UK) ABAEAdult Bovine Aortic Endothelial(cell biology) ABAEAssociation of Black Academic Employees(Illinois State University; Normal, IL) ...