This demonstrates that defects in potassium channels can cause epilepsy. Furthermore, some members of one of the BFNC families with a mutation in KCNQ2 also exhibited rolandic epilepsy and one individual with juvenile myoclonic epilepsy has a mutation in an alternative exon of KCNQ3.Singh, Nanda...
The blophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined. It is concluded that both these subunits contribute to the native M-current.关键词: Potassium Potassium Channels Anthracenes Indoles KCNQ2-protein KCNQ3...
KCNQ2 and KCNQ3 mutations contribute to different idiopathic epilepsy syndromes. To explore the involvement of M-type potassium channels KCNQ2, Q3, and Q5 in the pathogenesis of common idiopathic epilepsies.Sequence analysis of the KCNQ... B A,Neubauer,Waldegger,... - 《Neurology》 被引量: ...
Potassium channels, voltage-gated refseq数据库代号 NM_172109 更多... 基因染色体位置 基因染色体位置 20q13.33 基因简述 基因简述 The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by ...
and Villarroel A. (2008) Calmodulin regulates the trafficking of KCNQ2 potassium channels. FASEB J. 22: 1135-1143.Etxeberria, A., Aivar, P., Rodriguez-Alfaro, J. A., Alaimo, A., Villace, P., Gomez-Posada, J. C. et al. (2008). Calmodulin regulates the trafficking of KCNQ2 ...
Moreover, mutations in KCNQ2 and KCNQ3 genes have been shown to be associated with benign familial neonatal convulsions (54,55). Potassium channels in health, disease & development of channel modulators More results ► Dictionary browser ? ▲ Kazan Elia Kazan Retto Kazan River Kazantzakis Kazant...
产品介绍 :Epilepsy affects about 0.5% of the world’s population and has a large genetic component. Epilepsy results from an electrical hyperexcitability in the central nervous system. Potassium channels are important regulators of electrical signaling, determining the firing properties and responsiveness...
spanning the deleted region identified a novel voltage-gated potassium channel, KCNQ2, which belongs to a new KCNQ1-like class of potassium channels. Nine other BFNC probands were shown to have KCNQ2 mutations including three missense mutations, three frameshifts, two nonsense mutations, and one...
Activation of K+ channels induces apoptosis in vascular smooth muscle cells. Am J Physiol Cell Physiol 2001; 280: C970–C979. Article CAS Google Scholar Wei L, Xiao AY, Jin C, Yang A, Lu ZY, Yu SP . Effects of chloride and potassium channel blockers on apoptotic cell shrinkage and ...
钾离子通道蛋白家族KCNQ2抗体产品介绍 Epilepsy affects about 0.5% of the world’s population and has a large genetic component. Epilepsy results from an electrical hyperexcitability in the central nervous system. Potassium channels are important regulators of electrical signaling, determining the firing pr...