Clonally restricted B cells in periph- eral blood of multiple sclerosis patients: kappa/lambda staining pat- terns. Ann Neurol 1982;11:408 - 412.Hauser, S. L., H. L. Weiner & K. A. Ault: Clonally restricted B cells in peripheral blood of multiple sclerosis patients: kappa/lambda ...
The presence of both kappa- and lambda-light chain-restricted B-cell populations in B-cell lymphomas, including MALT lymphoma, is an unusual findings [16]. Edinger et al. reported 2 other examples of primary cutaneous marginal zone lymphomas that express both kappa- and lambda-light chain-...
Cells positive for either the kappa opioid receptor or both the kappa opioid receptor and preprodynorphin were restricted to the vasopressin expressing neuronal population and not found in the oxytocin expressing neuronal population. The kappa opioid receptor and dynorphin were examined in the posterior...
A pure population of light chain restricted B-cells is easy to recognize using flow cytometric immunophenotyping and is usually reflected in an abnormal kappa/lambda ratio. However, evaluation of the kappa to lambda ratio will not identify small clonal populations admixed with reactive polyclonal B-...
This ISRE is a multifunctional motif that also binds the LPS-inducible factor kappaBF-A and is located within the kappaBS region, which confers B cell specific activity to this enhancer. However, since the expression of IRF-1 is not restricted to B cells, it must not be sufficient for ...
NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that modulates transcription of DNA, cytokine generation and cell existence. NF-κB pathway has long been known as an ideal pro-inflammatory signaling path, mainly based on the role of NF-κB in the...
Expression of opioid receptor transcripts was restricted to subpopulations of neurons within most regions studied demonstrating differences in the cellular expression patterns of mu, kappa, and delta opioid receptor messenger RNAs in numerous brain regions. The messenger RNA distribution patterns for each ...
The brain distribution of RPTP-kappa-expressing cells has not been determined, however. In a gene-trap mouse model with a beta-gal + neo (kappa-geo) insertion in the endogenous RPTP-kappa gene, the consequent loss of RPTP-kappa's enzymatic activity does not produce any obvious phenotypic ...
[3] Spencer A, Augustson B, Mollee P, Copeman M, Asvadi P, Dunn R. Phase 2a, open-label, multi-dose study of the anti-kappa monoclonal antibody, MDX-1097, in relapsed kappa-chain restricted multiple myeloma with stable measurable disease. The European Hematology Association (EHA). Stockh...
Interestingly, constitutive KOR KO mice show equivalent levels of footshock-potentiated startle compared to wild type littermates, whereas KOR deletion restricted to DAT expressing neurons (DATCre KO) was sufficient to reduce potentiated startle following the first two blocks of footshock. This ...