Numerous studies have demonstrated elevated kappa free light chains (KFLCs) in CSF of multiple sclerosis (MS) patients. However, so far only small cohorts have been examined, and generally only through qualitative KFLCs analysis. Using a recently developed free light chain (FLC) immunoassay, it ...
Ele- vated levels of kappa free light chains in CSF support the diagnosis of multiple sclerosis. J. Neurol. 255: 1508-1514.Presslauer S, Milosavljevic D, Brucke T, et al. Elevated levels of kappa free light chains in CSF support the diagnosis of multiple sclerosis. J Neurol 2008;255:...
Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels > or = 1.53 microg/mL predicted progression to need for ambulatory ...
Kappa free light chains (KFLC) index has been described as a reliable marker of intrathecal immunoglobulin G (IgG) synthesis in multiple sclerosis (MS), resulting even more accurate than IgG index to discriminate MS from other neurological diseases1,2,3. Immunoglobulin free light chains (FLC), ...
Gertz MA. Immunoglobulin light chain amyloidosis: 2018 Update on diagnosis, prognosis, and treatment[J]. Am J Hematol. 2018;93(9):1169–80. Article CAS PubMed Google Scholar Hutchison CA, Cockwell, et al. Quantitative assessment of serum and urinary polyclonal free light chains in patients ...
These molecules are formed by two IgG4 heavy chains plus one κand one λlight chain. Because AIP is characterized by an elevated serum IgG4 concentration, we attempted to investigate the diagnostic utility of hybrid κ/λantibody in the diag- nosis of AIP and its ...
The paper deals with examination of free kappa light chains (FKLC) in the cerebrospinal fluid and serum of patients with multiple sclerosis (MS). The patient group included 84 women (mean age 34.03 ± 10.33 years) and 24 men (mean age 33.81 ± 10.61 years). The average disease duration ...
The complementary study identified free kappa light chains in urine (73,9 mg/dL) and bone marrow study fulfilled the criteria for multiple myeloma. Search for amyloid fibrils in abdominal subcutaneous fat was positive. The serum beta-2 microglobulin level was elevated (26 mg/L). Transthoracic ...
High sensitivity and specificity of elevated cerebrospinal fluid kappa free light chains in suspected multiple sclerosis. J Neuroimmunol 2014;276:175-9.Hassan-Smith, G., Durant, L., Tsentemeidou, A., Assi, L.K., Faint, J.M., Kalra, S., et al., 2014. High sensitivity and specificity...
The inhibition of SASP by metformin might contribute to the observed anti-aging effects post-metformin treatment [119]. 5.2. IKKβ in Antitumor Immune Responses One of the central mechanisms through which IKKβ contributes to antitumor immunity is the activation of immune cells, particularly T ...