Numerous studies have demonstrated elevated kappa free light chains (KFLCs) in CSF of multiple sclerosis (MS) patients. However, so far only small cohorts have been examined, and generally only through qualitative KFLCs analysis. Using a recently developed free light chain (FLC) immunoassay, it ...
Free Kappa light chain in a sample of Egyptian multiple sclerosis patients (a pilot study) Multiple sclerosis is a chronic autoimmune-mediated demyelinating disease of the central nervous system that is usually associated with varying degrees of ... AEA Shehab,SI Bakr,RM Saleh,... - 《Egyptian...
Isotype variants were based on human IgG1 (G1m(f) isotype) and IgG3 (P01860), all variants were co-expressed with kappa light chain. Gene constructs for heavy and light chains were designed to include a cleavable signal sequence for secretion and were flanked by restriction sites to allow...
Among SAD patients, 28.4% had raised total FLC (from 12% in RA to 30% in SLE and APS) with a normal kappa/lambda ratio. Total FLC levels were significantly higher in SAD with inflammation, active disease in SLE and SjS, and an impaired pulmonary functional capacity in SSc, while ...
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Inflammation regulates neurogenesis, and the brains of patients with schizophrenia and bipolar disorder have reduced expression of neurogenesis markers in the subependymal zone (SEZ), the birthplace of inhibitory interneurons. Inflammation is associated
Further investigation showed that this elevation may involve dysregulation of the nuclear factor kappa-light-chain enhancer of activated B cells (NF-kappa B) pathway and NF-kappa B-mediated transcription of inducible nitric oxide synthase (iNOS) as indicated by translocation of NF-kappa B to the ...
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Suppression of PTEN expression by NF-kappa B prevents apoptosis. Mol Cell Biol 2004; 24:1007-1021. 35 Hettinger K, Vikhanskaya F, Poh MK, et al. c-Jun promotes cellular survival by suppression of PTEN. Cell Death Differ 2007; 14:218-229. 36 Munro S, Pelham HR. An Hsp70-like ...
C. NF-[kappa]B and STAT3 Inhibition as a Therapeutic Strategy in Psoriasis: In Vitro and In Vivo Effects of BTH. J Invest Dermatol 133, 2362–2371 (2013). 30. Liang, J. et al. Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of ...